{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"089-289-564-005-202","frontPageModel":{"patentViewModel":{"ref":{"entityRefId":"089-289-564-005-202","entityRefType":"PATENT"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":8901,"type":"PATENT","title":"University of Michigan Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":14369,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8216,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners= \"Univ Michigan\", \" Michigan Univ\", \" Univ Michigan NOT state NOT tech NOT Eastern\", \"Univ Michigan NOT technological\", \" Univ Michigan NOT Western\"
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Total patent : 14104
Search Applicants and Owners= \"Univ Michigan\", \" Michigan Univ\", \" Univ Michigan NOT state NOT tech NOT Eastern\", \"Univ Michigan NOT technological\", \" Univ Michigan NOT Western\"
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Total patent : 14104
a) contacting a biological sample from a subject with at least a first gene fusion informative reagent selected from the group consisting of:\n
a nucleic acid probe that hybridizes to the fusion junction in a nucleic acid selected from the group consisting of SEQ NOs: 25 and 27-30;\n
a pair of probes wherein said first probe hybridizes to NAB2 and said second probe hybridizes to STAT6;\n
a pair of nucleic acid primers that amplify a nucleic acid selected from the group consisting of SEQ NOs: 25 and 27-30, wherein said primers amplify a fusion junction of the NAB2-STAT6 gene fusion; and\n
a sequencing primer that binds a nucleic acid selected from the group consisting of SEQ ID NO: 25 and 27-30 and generates an extension product that spans the fusion junction of said NAB2-STAT6 gene fusion;\n
(b) detecting the presence of a said NAB2-STAT6 gene fusion in said sample using said reagent by carrying out a hybridization reaction, amplification reaction or sequencing reaction appropriate to the reagent contacted."],"number":1,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein said reagent is a probe that specifically hybridizes to the fusion junction of a NAB2-STAT6 gene fusion."],"number":2,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein said reagent is a pair of primers that amplify a fusion junction of a NAB2-STAT6 gene fusion."],"number":3,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the reagent is a sequencing primer that binds to a NAB2-STAT6 fusion and generates an extension product that spans the fusion junction of said NAB2-STAT6 gene fusion."],"number":4,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein said regent comprises a pair of probes wherein said first probe hybridizes to NAB2 and said second probe hybridizes to an STAT6 gene."],"number":5,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein said reagent is labeled."],"number":6,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, further comprising the step of collecting said sample from said subject."],"number":7,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the sample is selected from the group consisting of tissue, blood, plasma, serum, and cells."],"number":8,"annotation":false,"claim":true,"title":false}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}