{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"089-245-598-707-267","frontPageModel":{"patentViewModel":{"ref":{"entityRefId":"089-245-598-707-267","entityRefType":"PATENT"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":10737,"type":"PATENT","title":"The University of British Columbia - Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":7923,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8233,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately:\"univ* briti* colum*\".
Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 7363
Search Applicants and Owners separately:\"univ* briti* colum*\".
Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 7363
(1) (a) providing a cell having reduced enzyme activity resulting in accumulation of undegraded or partially degraded GAGs, wherein the enzyme is involved in degrading GAGs and contacting the cell with one or more test compounds; or\n\n(b) providing a mucopolysaccharidoses (MPS) experimental animal having reduced enzyme activity resulting in an accumulation of undegraded or partially degraded GAGs and administering to the experimental animal one or more test compounds; and\n
(2) determining whether there is a relative increase or decrease of MPS marker as a result of the administration of one or more test compounds,\n
whereby any compound that promotes GAG degradation is identified."],"number":1,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein MPS marker is selected from one or more of the following markers:\n
Fibrinogen, γ-polypeptide; Fibrinogen, α-polypeptide; α-1-antitrypsin 1-5;\n
Inter-α trypsin inhibitor, heavy chain 1;\n
Apolipoprotein B;\n
Pzp protein; Gelsolin;\n
Kininogen precursor;\n
Histidine-rich glycoprotein;\n
Alpha-1 proteinase inhibitor 2;\n
Apolipoprotein C-III; Factor XIII beta;\n
Paraoxonase 1;\n
Heparin cofactor II thrombin complex (HCII-T); and\n
Heparin cofactor II (HCII)."],"number":2,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 2, wherein the one or more test compounds increases HCII levels, or wherein the one or more test compounds decreases HCII-T levels."],"number":3,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, further comprising administering any identified compound to a test subject."],"number":4,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, further comprising incorporating any identified compound into a medicament."],"number":5,"annotation":false,"claim":true,"title":false},{"lines":["A method for identifying an individual having mucopolysaccharidoses (MPS), or determining whether an individual is at risk for MPS, the method comprising:\n
testing at least one biological sample from the individual in an MPS marker detection assay, operable for determining relative MPS marker levels, wherein an MPS marker level different from the MPS marker level in a normal subject is indicative of MPS status."],"number":6,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 6, wherein MPS marker is selected from one or more of the following:\n
Fibrinogen, γ-polypeptide; Fibrinogen, α-polypeptide; α-1-antitrypsin 1-5;\n
Inter-α trypsin inhibitor, heavy chain 1;\n
Apolipoprotein B;\n
Pzp protein; Gelsolin;\n
Kininogen precursor;\n
Histidine-rich glycoprotein;\n
Alpha-1 proteinase inhibitor 2;\n
Apolipoprotein C-III;\n
Factor XIII beta;\n
Paraoxonase 1;\n
Heparin cofactor II thrombin complex (HCII-T), and\n
Heparin cofactor II (HCII)."],"number":7,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 6, wherein the MPS marker is HCII, and a decreased HCII level is indicative of MPS, or\n
wherein the MPS marker is HCII-T, and an increased HCII-T level is indicative of MPS."],"number":8,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 6, further comprising administering a treatment to the subject identified as having MPS or at risk for MPS."],"number":9,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 9, wherein the treatment comprises Aldurazyme® (laronidase) administration."],"number":10,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 9, wherein the treatment comprises a bone marrow transplant."],"number":11,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 9, wherein the biological sample is collected one or more times prior to, during or after treatment."],"number":12,"annotation":false,"claim":true,"title":false}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}