{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"084-891-867-735-675","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"084-891-867-735-675"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":10731,"type":"PATENT","title":"The University of North Carolina at Chapel Hill - Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":8887,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8232,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately:\"uni* north caro*\". Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 1000
Search Applicants and Owners separately:\"uni* north caro*\". Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 1000
(a) DNA having the nucleotide sequence of SEQ ID NO: 1;
(b) polynucleotides that hybridise to a complement of the DNA of (a) above under stringent conditions and which encode ROC1;
(c) polynucleotides that differ from the DNA of (a) or (b) above due to the degeneracy of the genetic code, and that encode ROC1 encoded by a DNA of (a) or (b) above; and
(d) polynucleotides at least 85% identical to SEQ ID NO: 1 and which encode ROC1."],"number":1,"annotation":false,"title":false,"claim":true},{"lines":["The polynucleotide of claim 1 (d) wherein the polynucleotide is at least 95% identical to SEQ ID NO: 1."],"number":2,"annotation":false,"title":false,"claim":true},{"lines":["An isolated polynucleotide according to claim 1 that encodes ROC 1."],"number":3,"annotation":false,"title":false,"claim":true},{"lines":["An isolated polynucleotide according to claim 1 that encodes ROC1 having the amino acid sequence given herein as SEQ ID NO: 2."],"number":4,"annotation":false,"title":false,"claim":true},{"lines":["An isolated polynucleotide according to claim 1 which is a DNA having the nucleotide sequence given herein as SEQ ID NO: 1."],"number":5,"annotation":false,"title":false,"claim":true},{"lines":["An expression vector comprising a nucleic acid according to claim 1."],"number":6,"annotation":false,"title":false,"claim":true},{"lines":["A cell containing an expression vector according to claim 6."],"number":7,"annotation":false,"title":false,"claim":true},{"lines":["A cell containing an expression vector according to claim 7 and capable of expressing ROC1."],"number":8,"annotation":false,"title":false,"claim":true},{"lines":["An antibody which specifically binds to a protein encoded by a polynucleotide according to claim 1."],"number":9,"annotation":false,"title":false,"claim":true},{"lines":["An antibody according to claim 10, wherein said antibody is a polyclonal antibody"],"number":10,"annotation":false,"title":false,"claim":true},{"lines":["An antibody according to claim 10, wherein said antibody is a monoclonal antibody."],"number":11,"annotation":false,"title":false,"claim":true},{"lines":["An antisense oligonucleotide complementary to a polynucleotide of claim 1 and having a length sufficient to hybridize thereto under physiological conditions."],"number":12,"annotation":false,"title":false,"claim":true},{"lines":["A DNA encoding an antisense oligonucleotide of claim 12."],"number":13,"annotation":false,"title":false,"claim":true},{"lines":["An expression vector comprising an antisense oligonucleotide according to claim 12."],"number":14,"annotation":false,"title":false,"claim":true},{"lines":["A method for producing a protein comprising the amino acid sequence of SEQ ID NO: 2, or a fragment thereof, comprising:
(a) culturing a host cell containing an expression vector containing at least a fragment of the polynucleotide sequence encoding ROC1 under conditions suitable for the expression of the protein; and
(b) recovering the protein from the host cell culture."],"number":15,"annotation":false,"title":false,"claim":true},{"lines":["A method for detecting a polynucleotide which encodes ROC1 in a biological sample comprising:
(a) hybridizing the complement of the polynucleotide sequence which encodes SEQ ID NO: 1 to nucleic acid material of a biological sample, thereby forming a hybridization complex; and
(b) detecting the hybridization complex, wherein the presence of the complex correlates with the presence of a polynucleotide encoding ROC1 in the biological sample."],"number":16,"annotation":false,"title":false,"claim":true},{"lines":["A method for screening for a bioactive agent capable of binding to a ROC1 protein, said method comprising:
(a) combining a ROC1 protein and a candidate bioactive agent; and
(b) determining the binding of said candidate bioactive agent to said ROC1 protein."],"number":17,"annotation":false,"title":false,"claim":true},{"lines":["A method for screening for a bioactive agent capable of interfering with the binding of a ROC1 protein and a cullin protein, said method comprising:
(a) combining a ROC1 protein, a candidate bioactive agent and a cullin protein; and
(b) determining the binding of said ROC1 protein and said cullin protein."],"number":18,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 18, wherein the cullin protein is selected from the group consisting of cullin 1, cullin 2, cullin 3, cullin 4A and cullin 5."],"number":19,"annotation":false,"title":false,"claim":true},{"lines":["A method of screening for a bioactive agent capable of modulating the activity of a ROC1 protein said method comprising:
(a) combining a ROC1 protein and a candidate bioactive agent; and
(b) determining the effect of said candidate bioactive agent on the activity of said ROC1 protein."],"number":20,"annotation":false,"title":false,"claim":true},{"lines":["A method of screening for a bioactive agent capable of modulating the activity of ROC1 proteins, said method comprising:
(a) adding a candidate bioactive agent to a cell comprising a recombinant nucleic acid encoding a ROC1 protein; and
(b) determining the effect of said candidate bioactive agent on said cell."],"number":21,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}