{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"077-890-017-223-528","frontPageModel":{"patentViewModel":{"ref":{"entityRefId":"077-890-017-223-528","entityRefType":"PATENT"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":8758,"type":"PATENT","title":"California Institute of Technology","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":14069,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8202,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Searched: California Institute of Technology
","published":true,"created":"2015-11-19T02:35:22Z","updated":"2017-08-07T00:27:53Z","sharedType":"PUBLISHED","collectionId":8758,"collectionTitle":"California Institute of Technology","collectionType":"PATENT"}],"sharedType":"PUBLISHED","hasLinkedSavedQueries":false,"savedQueries":[],"created":"2015-11-19T02:35:22Z","updated":"2018-03-15T04:30:55Z","lastEventDate":"2018-03-15T04:30:55Z"},{"id":8760,"type":"PATENT","title":"California Institute of Technology","description":"Search applicant and Owners= \"California Inst Tech\", \"California Institute of Technology\", \" Inst California Tech*\".
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\n","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":9988,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[],"sharedType":"PUBLISHED","hasLinkedSavedQueries":false,"savedQueries":[],"created":"2015-11-19T03:31:37Z","updated":"2015-12-07T02:37:23Z","lastEventDate":"2015-12-07T02:37:23Z"},{"id":10771,"type":"PATENT","title":"University of Southern California - Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":8387,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8241,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"Searched: California Institute of Technology
","published":true,"created":"2015-11-19T02:35:22Z","updated":"2017-08-07T00:27:53Z","sharedType":"PUBLISHED","collectionId":8758,"collectionTitle":"California Institute of Technology","collectionType":"PATENT"}],"sharedType":"PUBLISHED","hasLinkedSavedQueries":false,"savedQueries":[],"created":"2015-11-19T02:35:22Z","updated":"2018-03-15T04:30:55Z","lastEventDate":"2018-03-15T04:30:55Z"},{"id":8760,"type":"PATENT","title":"California Institute of Technology","description":"Search applicant and Owners= \"California Inst Tech\", \"California Institute of Technology\", \" Inst California Tech*\".
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Total patents: more than 10k.
\n","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":9988,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[],"sharedType":"PUBLISHED","hasLinkedSavedQueries":false,"savedQueries":[],"created":"2015-11-19T03:31:37Z","updated":"2015-12-07T02:37:23Z","lastEventDate":"2015-12-07T02:37:23Z"},{"id":10771,"type":"PATENT","title":"University of Southern California - Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":8387,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8241,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"a top porous membrane having top membrane pores;\n
a bottom porous membrane having bottom membrane pores, wherein several bottom membranes pores are distributed in the bottom porous membrane to be horizontally offset from several top membrane pores distributed in the top porous membrane; and\n
a gap separating the top porous membrane and the bottom porous membrane, wherein a gap distance between the top porous membrane and the bottom porous membrane provide by the gap is sized larger than particles not to be captured by the microfiltration patch."],"number":1,"annotation":false,"claim":true,"title":false},{"lines":["The microfiltration patch according to claim 1, wherein diameters of several top membrane pores are sized to capture particles having selected particle diameters and the gap distance positions the bottom porous membrane to provide back pressure to particles captured within at least one of the top membrane pores."],"number":2,"annotation":false,"claim":true,"title":false},{"lines":["The microfiltration patch according to claim 2, wherein the top membrane pores and bottom membrane pores have diameters greater than diameters of blood cells and smaller than diameters of circulating tumor cells and wherein the gap distance is smaller than the diameters of the circulating tumor cells."],"number":3,"annotation":false,"claim":true,"title":false},{"lines":["The microfiltration patch according to claim 1, wherein diameters of several top membrane pores are sized larger than particle diameters of particles to be captured and diameters of the bottom membrane pores are sized smaller than particle diameters of particles to be captured and the gap distance is smaller than particle diameters of particles to be captured."],"number":4,"annotation":false,"claim":true,"title":false},{"lines":["The microfiltration patch according to claim 4, wherein the bottom membrane pores have diameters greater than diameters of blood cells and smaller than diameters of circulating tumor cells and wherein the gap distance is smaller than the diameters of the circulating tumor cells."],"number":5,"annotation":false,"claim":true,"title":false},{"lines":["The microfiltration patch according to claim 1, wherein the top porous membrane and/or bottom porous membrane comprises parylene."],"number":6,"annotation":false,"claim":true,"title":false},{"lines":["The microfiltration patch according to claim 3, wherein the top membrane pores have diameters of approximately 9 micrometers, the bottom membrane pores have diameters of approximately 8 micrometers and the gap distance is approximately 6.5 micrometers."],"number":7,"annotation":false,"claim":true,"title":false},{"lines":["The microfiltration patch according to claim 5, wherein the top membrane pores have diameters of approximately 40 micrometers, the bottom membrane pores have diameters of approximately 8 micrometers and the gap distance is approximately 5.5 micrometers."],"number":8,"annotation":false,"claim":true,"title":false},{"lines":["The microfiltration patch according to claim 4, wherein the top membrane pores have diameters of approximately 40 micrometers, the bottom membrane pores have diameters of approximately 8 micrometers and the gap size is approximately 5.5 micrometers."],"number":9,"annotation":false,"claim":true,"title":false},{"lines":["A microfiltration array comprising several microfiltration patches according to claim 1, wherein each microfiltration patch comprises top membrane pores arranged in a first hexagonal array and bottom membrane pores arranged in a second hexagonal array, and wherein the several microfiltration patches are arranged in an array of microfiltration patches, wherein the several microfiltration patches are separated from one another by areas in which the top membrane contacts the bottom membrane."],"number":10,"annotation":false,"claim":true,"title":false},{"lines":["A microfiltration array comprising several microfiltration patches according to claim 1, wherein the bottom membrane pores are distributed in hexagonal arrays around a center area defined by the locations of the top membrane pores, and wherein the several microfiltration patches are arranged in an array of microfiltration patches, wherein the several microfiltration patches are separated from one another by areas in which the top porous membrane contacts the bottom porous membrane."],"number":11,"annotation":false,"claim":true,"title":false},{"lines":["A microfiltration system comprising one or more microfiltration arrays according to claim 10, wherein the several microfiltration patches are formed within at least a portion of a silicon wafer and wherein the microfiltration system further comprises:\n
an upper area located above the top porous membranes of the microfiltration patches, wherein the upper area is pressurizable, and\n
a lower area located beneath the bottom porous membranes of the microfiltration patches, wherein the lower area is configured to allow reception of fluids."],"number":12,"annotation":false,"claim":true,"title":false},{"lines":["A microfiltration system comprising one or more microfiltration arrays according to claim 11, wherein the several microfiltration patches comprise two parylene layers and wherein the microfiltration system further comprises:\n
an upper area located above the top porous membranes of the microfiltration patches, wherein the upper area is pressurizable, and\n
a lower area located beneath the bottom porous membranes of the microfiltration patches, wherein the lower area is configured to allow reception of fluids."],"number":13,"annotation":false,"claim":true,"title":false},{"lines":["A method for capturing selected cells from a fluid sample, wherein the method comprises:\n
applying the fluid sample to a first membrane having several first membrane pores;\n
flowing the fluid sample through the several first membrane pores into a gap defined by a distance between the first membrane and a second membrane, wherein the distance between the first membrane and the second membrane is smaller than the diameters of the cells to be captured; and\n
flowing the fluid sample through several second membrane pores in the second membrane,\n
wherein the second membrane pores are located in the second membrane so as not to be directly beneath the first membrane pores located in the first membrane."],"number":14,"annotation":false,"claim":true,"title":false},{"lines":["The method according to claim 14, wherein one or more of the first membrane pores have diameters smaller than diameters of the particles to be captured, whereby one or more of the cells to be captured become wedged in one or more of the several first membrane pores, and the locations of the first membrane pores and the second membrane pores and the distance between the first membrane and the second membrane are chosen such that a back pressure to one or more of the wedged cells, wherein the back pressure is applied in a direction roughly opposite to a fluidic pressure applied to the one or more wedged particles."],"number":15,"annotation":false,"claim":true,"title":false},{"lines":["The method according to claim 14, wherein the first membrane pores have diameters larger than the cells to be captured."],"number":16,"annotation":false,"claim":true,"title":false},{"lines":["The method according to claim 14, wherein applying the fluid to the first membrane comprises applying the fluid at a pressure."],"number":17,"annotation":false,"claim":true,"title":false},{"lines":["The method according to claim 14, wherein the first membrane and/or the second membrane comprises parylene."],"number":18,"annotation":false,"claim":true,"title":false},{"lines":["The method according to claim 14, further comprising performing cell detection."],"number":19,"annotation":false,"claim":true,"title":false},{"lines":["The method according to claim 19, further comprising culturing captured cells for a chosen length of time."],"number":20,"annotation":false,"claim":true,"title":false},{"lines":["The method according to claim 16, further comprising:\n
separating the first membrane from the second membrane; and\n
performing cell detection."],"number":21,"annotation":false,"claim":true,"title":false},{"lines":["A method for fabricating a microfiltration device for the capture of chosen cell types from a fluid sample, wherein the method comprises:\n
depositing a first parylene layer on a front side of at least a portion of a silicon layer;\n
etching one or more cavities into a back side of the at least a portion of the silicon layer;\n
depositing a second parylene layer on both the front side and the back side of the at least a portion of the silicon layer;\n
creating several bottom layer pores in the first parylene layer and the second parylene layer within the one or more cavities;\n
depositing a photoresist layer above the several bottom layer pores;\n
depositing a third parylene layer above the photoresist layer and the second parylene layer on the front side;\n
creating several top layer pores in the third parylene layer above the one or more cavities; and,\n
removing the photoresist layer."],"number":22,"annotation":false,"claim":true,"title":false},{"lines":["The method according to claim 22, further comprising annealing the microfiltration device after deposition of all three parylene layers."],"number":23,"annotation":false,"claim":true,"title":false},{"lines":["The method according to claim 22, wherein diameters of the bottom layer pores and the top layer pores are chosen to be smaller than diameters of cells to be captured by the microfiltration device."],"number":24,"annotation":false,"claim":true,"title":false},{"lines":["The method according to claim 22, wherein the thickness of the photoresist layer is chosen to be smaller than diameters of the cells to be captured by the microfiltration device."],"number":25,"annotation":false,"claim":true,"title":false},{"lines":["A method for fabricating a microfiltration device for the capture of chosen cell types from a fluid sample, wherein the method comprises:\n
depositing a first parylene layer on a at least a portion of a silicon layer;\n
creating several bottom layer pores in the first parylene layer;\n
depositing a photoresist layer above the several bottom layer pores;\n
etching the photoresist layer to form layer contact areas;\n
depositing a second parylene layer above the photoresist layer;\n
creating several top layer pores in the second parylene layer;\n
removing the photoresist layer; and\n
releasing the first parylene layer from the silicon layer."],"number":26,"annotation":false,"claim":true,"title":false},{"lines":["The method according to claim 26, wherein diameters of the bottom layer pores are chosen to be smaller than diameters of cells to be captured by the microfiltration device."],"number":27,"annotation":false,"claim":true,"title":false},{"lines":["The method according to claim 26, wherein the thickness of the photoresist layer is chosen to be smaller than diameters of the cells to be captured by the microfiltration device."],"number":28,"annotation":false,"claim":true,"title":false}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}