{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"069-780-229-625-142","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"069-780-229-625-142"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":6812,"type":"PATENT","title":"UNSW 2","description":"
Search Applicants= ' University of New South Wales' , ' Univ New South Wales' , ' UNSW', ' Univ* New Sou* Wal*' 'New Sou* Wal* Univ*', 'Univ* NEAR Ne* Sou* Wal*', 'Univ* AND Ne* Sou* Wal*'
Search Owners(US) = ' University of New South Wales' , ' Univ New South Wales' , ' UNSW', ' \nUniv* New Sou* Wal*' 'New Sou* Wal* Univ*', 'Univ* NEAR Ne* Sou* Wal*', \n'Univ* AND Ne* Sou* Wal*'
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\n","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":1583,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[],"sharedType":"PUBLISHED","hasLinkedSavedQueries":false,"savedQueries":[],"created":"2015-05-04T06:37:15Z","updated":"2015-06-01T02:42:40Z","lastEventDate":"2015-06-01T02:42:40Z"},{"id":11644,"type":"PATENT","title":"The University of New South Wales - Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":1800,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8310,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"Search Applicants and Owners separately:new AND south AND wale
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Search Applicants= ' University of New South Wales' , ' Univ New South Wales' , ' UNSW', ' Univ* New Sou* Wal*' 'New Sou* Wal* Univ*', 'Univ* NEAR Ne* Sou* Wal*', 'Univ* AND Ne* Sou* Wal*'
Search Owners(US) = ' University of New South Wales' , ' Univ New South Wales' , ' UNSW', ' \nUniv* New Sou* Wal*' 'New Sou* Wal* Univ*', 'Univ* NEAR Ne* Sou* Wal*', \n'Univ* AND Ne* Sou* Wal*'
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\n","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":1583,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[],"sharedType":"PUBLISHED","hasLinkedSavedQueries":false,"savedQueries":[],"created":"2015-05-04T06:37:15Z","updated":"2015-06-01T02:42:40Z","lastEventDate":"2015-06-01T02:42:40Z"},{"id":11644,"type":"PATENT","title":"The University of New South Wales - Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":1800,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8310,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"Search Applicants and Owners separately:new AND south AND wale
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\n\nA-[(XBX′)nB′-Y]p (I)\n\n
wherein\n
A is selected from the group consisting of glutathione, glucosamine, cysteinylglycine, cysteic acid, aspartic acid, glutamic acid, lysine, and arginine, and wherein the sulfur atom of each sulfur containing compound may be optionally oxidised to form a sulfoxide or sulfone;\n
X is selected from the group consisting of: NR—, S(O)—, —S(O)O—, —S(O)2—, —S(O)2O—, —C(O)—, —C(S)—, —C(O)O—, C(S)O—, —C(S)S—, —P(O)(R1)—, —P(O)(R1)O—, or is absent;\n
B is selected from C1-C10 alkylene, C2-C10 alkenylene, C2-C10 alkynylene, C3-C10 cycloalkylene, C5-C10 cycloalkenylene, C3-C10 heterocycloalkylene, C5-C10 heterocycloalkenylene, C6-C12arylene, heteroarylene or C2-C10acyl;\n
X′ is selected from NR—, —O—, —S—, —Se—, —S—S—, S(O)—, —OS(O)—, OS(O)O—, —OS(O)2, —OS(O)2O—, —S(O)O—, —S(O)2—, —S(O)2O—, —OP(O)(R1)—, —OP(O)(R1)O—, —OP(O)(R1)OP(O)(R1)O—, —C(O)—, —C(S)—, —C(O)O—, C(S)O—, —C(S)S—, —P(O)(R1)—, —P(O)(R1)O—,\n\n
or is absent; wherein E is O, S, Se, NR or NR2+; and\n
B′ is C1-C10 alkylene, C2-C10 alkenylene, C2-C10 alkynylene, C3-C10 cycloalkylene, C5-C10 cycloalkenylene, C3-C10 heterocycloalkylene, C5-C10 heterocycloalkenylene, C6-C12 arylene, and heteroarylene, or is absent; and wherein\n
each R is independently selected from hydrogen, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C3-C10 cycloalkyl, C5-C10 cycloalkenyl, C3-C10 heterocycloalkyl, C5-C10 heterocycloalkenyl, C6-C12 aryl, heteroaryl, OR2 or C2-C10 acyl;\n
R′ is the same as R or two R′ may be taken together with the nitrogen atoms to which they are attached to form a 5 or 6-membered saturated or unsaturated heterocyclic ring;\n
each R1 is independently selected from hydrogen, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C3-C10 cycloalkyl, C5-C10 cycloalkenyl, C3-C10 heterocycloalkyl, C5-C10 heterocycloalkenyl, C6-C12 aryl, heteroaryl, halo, OR2 or N(R)2;\n
each R2 is independently selected from hydrogen, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C3-C10 cycloalkyl, C5-C10 cycloalkenyl, C3-C10 heterocycloalkyl, C5-C10 heterocycloalkenyl, C6-C12 aryl, heteroaryl or —C(O)R5;\n
each R5 is independently selected from hydrogen, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C3-C10 cycloalkyl, C5-C10 cycloalkenyl, C3-C10 heterocycloalkyl, C5-C10 heterocycloalkenyl, C6-C12 aryl, heteroaryl, C1-C10 alkoxy, C3-C10 alkenyloxy, C3-C10 alkynyloxy, C3-C10 cycloalkyloxy, C5-C10 cycloalkenyloxy, C3-C10 heterocycloalkyloxy, C5-C10 heterocycloalkenyloxy, C6-C12 aryloxy, heteroaryloxy, C1-C10 alkylthio, C3-C10 alkenylthio, C3-C10 alkynylthio, C3-C10 cycloalkylthio, C5-C10 cycloalkenylthio, C3-C10 heterocycloalkylthio, C5-C10 heterocycloalkenylthio, C6-C12 arylthio, heteroarylthio, OH, SH or N(R)2;\n
wherein for each instance that B and/or B′ is arylene, the substituents directly attached to the respective arylene rings (including arsenoxide) may be in a para, meta or ortho relationship, and\n
wherein each alkylene, alkenylene, alkynylene, cycloalkylene, cycloalkenylene, heterocycloalkylene, heterocycloalkenylene, arylene, heteroarylene and acyl may be independently substituted with hydrogen, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C3-C10 cycloalkyl, C5-C10 cycloalkenyl, C3-C10 heterocycloalkyl, C5-C10 heterocycloalkenyl, C6-C12 aryl, heteroaryl, halo, cyano, cyanate, isocyanate, OR2a, SR6, nitro, arsenoxide, —S(O)R3, —OS(O)R3, —S(O)2R3, —OS(O)2R3, —P(O)R4R4, —OP(O)R4R4, —N(R″)2, —NRC(O)(CH2)mQ, —C(O)R5,\n\nwherein R, R1 and R5 are as defined above; and\n
R2a is selected from hydrogen, C1-C5 alkyl, C2-C5 alkenyl, C2-C5 alkynyl, C3-C10 cycloalkyl, C5-C10 cycloalkenyl, C6-C12 aryl, —S(O)R3, —S(O)2R3, —P(O)(R4)2, N(R)2 or —C(O)R5;\n
each R3 is independently selected from hydrogen, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C3-C10 cycloalkyl, C5-C10 cycloalkenyl, C3-C10 heterocycloalkyl, C5-C10 heterocycloalkenyl, C6-C12 aryl, heteroaryl, C1-C10 alkoxy, C3-C10 alkenyloxy, C3-C10 alkynyloxy, C3-C10 cycloalkyloxy, C5-C10 cycloalkenyloxy, C3-C10 heterocycloalkyloxy, C5-C10 heterocycloalkenyloxy, C6-C12 aryloxy, heteroaryloxy, C1-C10 alkylthio, C3-C10 alkenylthio, C3-C10 alkynylthio, C3-C10 cycloalkylthio, C5-C10 cycloalkenylthio, C3-C10 heterocycloalkylthio, C5-C10 heterocycloalkenylthio, C6-C12 arylthio, heteroarylthio or N(R)2;\n
each R4 is independently selected from hydrogen, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C3-C10 cycloalkyl, C5-C10 cycloalkenyl, C3-C10 heterocycloalkyl, C5-C10 heterocycloalkenyl, C6-C12 aryl, heteroaryl, C1-C10 alkoxy, C3-C10 alkenyloxy, C3-C10 alkynyloxy, C3-C10 cycloalkyloxy, C5-C10 cycloalkenyloxy, C3-C10 heterocycloalkyloxy, C5-C10 heterocycloalkenyloxy, C6-C12 aryloxy, heteroaryloxy, C1-C10 alkylthio, C3-C10 alkenylthio, C3-C10 alkynylthio, C3-C10 cycloalkylthio, C5-C10 cycloalkenylthio, C5-C10 heterocycloalkylthio, C5-C10 heterocycloalkenylthio, C6-C12 arylthio, heteroarylthio, halo or N(R)2;\n
R6 is selected from C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C3-C10 cycloalkyl, C5-C10 cycloalkenyl, C3-C10 heterocycloalkyl, C5-C10 heterocycloalkenyl, C6-C12 aryl, heteroaryl, C1-C10 alkylthio, C3-C10 alkenylthio, C3-C10 alkynylthio, C3-C10 cycloalkylthio, C5-C10 cycloalkenylthio, C3-C10 heterocycloalkylthio, C5-C10 heterocycloalkenylthio, C6-C12 arylthio, heteroarylthio, —S(O)R3, —S(O)2R3 or —C(O)R5,\n
R″ is the same as R or two R″ taken together with the N atom to which they are attached may form a saturated, unsaturated or aromatic heterocyclic ring system;\n
Q is selected from halogen and —OS(O)2Q1; wherein Q1 is selected from C1-C4 alkyl, C1-C4 perfluoroalkyl, phenyl, p-methylphenyl;\n
M is an integer selected from 1 to 5,\n
Y comprises at least one arsenoxide group;\n
p is an integer from 1 to 10; and\n
wherein the sum total of carbon atoms in A and (XBX′)nB′ together, is greater than 6; and wherein the cancer is a solid tumor."],"number":1,"annotation":false,"title":false,"claim":true},{"lines":["The method according to claim 1, wherein\n
X is selected from the group consisting of NR—, —C(O)—, —C(S)—, —C(O)O—, —C(S)O—, —C(S)S—, or is absent;\n
B is selected from C1-C5 alkylene, C2-C5 alkenylene, C2-C5 alkynylene, C3-C10 cycloalkylene, C5-C10 cycloalkenylene, C6-C12 arylene or C2-C5 acyl;\n
X′ is selected from —O—, —S—, —NR—, —S—S—, —S(O)—, —S(O)2—, —P(O)(R1)—, —OP(O)(R1)—, OP(O)(R1)O—, —OP(O)(R1)OP(O)(R1)O—, —C(O)—, —C(S)—, —C(O)O—, —C(S)O—, —C(S)S—, —Se—,\n\n
or is absent; wherein E is O, S or N(R)2+;\n\nn is 0, 1 or 2; and\n
B′ is C1-C5 alkylene, C2-C5 alkenylene, C2-C5 alkynylene, C3-C10 cycloalkylene, C5-C10 cycloalkenylene, C6-C12 arylene or is absent; and wherein\n
each R is independently selected from hydrogen, C1-C5 alkyl, C2-C5 alkenyl, C2-C5 alkynyl, C3-C10 cycloalkyl, C5-C10 cycloalkenyl, C6-C12 aryl, OR2 or C2-C10 acyl;\n
R′ is the same as R;\n
each R1 is independently selected from hydrogen, C1-C5 alkyl, C2-C5 alkenyl, C2-C5 alkynyl, C3-C10 cycloalkyl, C5-C10 cycloalkenyl, C6-C12 aryl, halo, OR2 or N(R)2;\n
each R2 is independently selected from hydrogen, C1-C5 alkyl, C2-C5 alkenyl, C2-C5 alkynyl, C3-C10 cycloalkyl, C5-C10 cycloalkenyl, C6-C12 aryl or —C(O)R5;\n
each R5 is independently selected from hydrogen, C1-C5 alkyl, C2-C5 alkenyl, C2-C5 alkynyl, C3-C10 cycloalkyl, C5-C10 cycloalkenyl, C6-C12 aryl, C1-C5 alkoxy, C3-C5 alkenyloxy, C3-C5 alkynyloxy, C3-C10 cycloalkyloxy, C5-C10 cycloalkenyloxy, C6-C12 aryloxy, C1-C5 alkylthio, C3-C5 alkenylthio, C3-C5 alkynylthio, C3-C10 cycloalkylthio, C5-C10 cycloalkenylthio, C6-C12 arylthio, OH, SH or N(R)2;\n
wherein each instance of arylene may have substituents A and X or X and Y in a para, meta or ortho relationship, and\n
wherein each alkylene, alkenylene, alkynylene, cycloalkylene, cycloalkenylene, arylene, and acyl may be independently substituted with hydrogen, C1-C5 alkyl, C2-C5 alkenyl, C2-C5 alkynyl, C3-C10 cycloalkyl, C5-C10 cycloalkenyl, C6-C12 aryl, halo, cyanate, isocyanate, OR2a, SR6, nitro, arsenoxide, —S(O)R3, —OS(O)R3, —S(O)2R3, —OS(O)2R3, —P(O)R4R4, —OP(O)R4R4, —N(R″)2, NRC(O)(CH2)mQ, —C(O)R5,\n\n
wherein R, R1 and R5 are as defined above; and\n
R2a selected from hydrogen, C1-C5 alkyl, C2-C5 alkenyl, C2-C5 alkynyl, C3-C10 cycloalkyl, C5-C10 cycloalkenyl, C6-C12 aryl, —S(O)R3, —S(O)2R3, —P(O)(R4)2, N(R)2 or —C(O)R5;\n
each R3 is independently selected from hydrogen, C1-C5 alkyl, C2-C5 alkenyl, C2-C5 alkynyl, C3-C10 cycloalkyl, C5-C10 cycloalkenyl, C6-C12 aryl, C1-C5 alkoxy, C3-C5 alkenyloxy, C3-C5 alkynyloxy, C3-C10 cycloalkyloxy, C5-C10 cycloalkenyloxy, C6-C12 aryloxy, C1-C5 alkylthio, C3-C5 alkenylthio, C3-C5 alkynylthio, C3-C10 cycloalkylthio, C5-C10 cycloalkenylthio, C6-C12 arylthio or N(R)2;\n
each R4 is independently selected from hydrogen, C1-C5 alkyl, C2-C5 alkenyl, C2-C5 alkynyl, C3-C10 cycloalkyl, C5-C10 cycloalkenyl, C6-C12 aryl, C1-C5 alkoxy, C3-C5 alkenyloxy, C3-C5 alkynyloxy, C3-C10 cycloalkyloxy, C5-C10 cycloalkenyloxy, C6-C12 aryloxy, C1-C5 alkylthio, C3-C5 alkenylthio, C3-C5 alkynylthio, C3-C5 cycloalkylthio, C5-C5 cycloalkenylthio, C6-C12 arylthio, halo or N(R)2;\n
R6 is independently selected from C1-C5 alkyl, C2-C5 alkenyl, C2-C5 alkynyl, C3-C10 cycloalkyl, C5-C10 cycloalkenyl, C6-C12 aryl, C1-C5 alkylthio, C3-C5 alkenylthio, C3-C5 alkynylthio, C3-C10 cycloalkylthio, C5-C10 cycloalkenylthio, C6-C12 arylthio, —S(O)R3, —S(O)2R3 or —C(O)R5;\n
R″ is the same as R;\n
Q is selected from halogen and —OS(O)2Q1; wherein Q1 is selected from C1-C4 alkyl, C1-C4 perfluoroalkyl, phenyl, p-methylphenyl; and\n
m is 1 to 5."],"number":2,"annotation":false,"title":false,"claim":true},{"lines":["The method according to claim 1, wherein\n
X is absent;\n
B is selected from C1-C5 alkylene, C6-C12 arylene or C2-C5 acyl;\n
X′ is selected from —O—, —S—, —NR—, —S—S—, —S(O)—, —S(O)2—, —P(O)(R1)—, —C(O)—, —C(S)—, —C(O)O—, —C(S)O—, —Se—,\n\n
or absent; wherein E is O, S or N(R)2+;\n\nn is 0, 1 or 2; and\n
B′ is C1-C5 alkylene, C6-C12 arylene or is absent; and wherein\n
each R is independently selected from hydrogen, C1-C5 alkyl, C3-C10 cycloalkyl, C6-C12 aryl, OR2 or C2-C5 acyl;\n
R′ is the same as R;\n
each R1 is independently selected from hydrogen, C1-C5 alkyl, C3-C10 cycloalkyl, C6-C12 aryl, halo, OR2 or N(R)2;\n
each R2 is independently selected from hydrogen, C1-C5 alkyl, C3-C10 cycloalkyl, C6-C12 aryl or —C(O)R5;\n
each R5 is independently selected from hydrogen, C1-C5 alkyl, C2-C5 alkenyl, C3-C10 cycloalkyl, C5-C10 cycloalkenyl, C6-C12 aryl, C1-C5 alkoxy, C3-C5 alkenyloxy, C3-C10 cycloalkyloxy, C5-C10 cycloalkenyloxy, C6-C12 aryloxy, C1-C5 alkylthio, C3-C5 alkenylthio, C3-C10 cycloalkylthio, C5-C10 cycloalkenylthio, C6-C12 arylthio, OH, SH or N(R)2;\n
wherein for each instance that B and/or B′ is arylene, the substituents directly attached to the respective arylene rings (including arsenoxide), may be in a para, meta or ortho relationship, and\n
wherein each alkylene, alkenylene, alkynylene, cycloalkylene, cycloalkenylene, arylene, and acyl may be independently substituted with hydrogen, C1-C5 alkyl, C2-C5 alkenyl, C2-C5 alkynyl, C3-C10 cycloalkyl, C5-C10 cycloalkenyl, C6-C12 aryl, halo, cyano, cyanate, isocyanate, OR2a, SR6, nitro, arsenoxide, —S(O)R3, —OS(O)R3, —S(O)2R3, —OS(O)2R3, —P(O)R4R4, —OP(O)R4R4, —N(R″)2, —NRC(O)(CH2)mQ, —C(O)R5,\n\n
wherein R, R1 and R5 are as defined above; and\n\nR2a is selected from hydrogen, C1-C5 alkyl, C3-C10 cycloalkyl, C6-C12 aryl, —S(O)R3, —S(O)2R3, —P(O)(R4)2 and —C(O)R5;\n
each R3 is independently selected from hydrogen, C1-C5 alkyl, C3-C10 cycloalkyl, C6-C12 aryl, C1-C5 alkoxy, C3-C10 cycloalkyloxy, C6-C12 aryloxy, C1-C5 alkylthio, C3-C10 cycloalkylthio, C6-C12 arylthio or N(R)2;\n
each R4 is independently selected from hydrogen, C1-C5 alkyl, C3-C10 cycloalkyl, C6-C12 aryl, C1-C5 alkoxy, C3-C10 cycloalkyloxy, C6-C12 aryloxy, halo or N(R)2;\n
R6 is selected from C1-C5 alkyl, C3-C10 cycloalkyl, C6-C12 aryl, C1-C5 alkylthio, C3-C10 cycloalkylthio, C6-C12 arylthio, —S(O)R3, —S(O)2R3 or —C(O)R5;\n\nR″ is the same as R;\n
Q is selected from halogen and —OS(O)2Q1; wherein Q1 is selected from C1-C4 alkyl, C1-C4 perfluoroalkyl, phenyl, p-methylphenyl; and\n
m is 1 to 5."],"number":3,"annotation":false,"title":false,"claim":true},{"lines":["The method according to claim 1, wherein\n
X is absent;\n
B is selected from C1-C5 alkylene, C6-C12 arylene or C2-C5 acyl;\n
X′ is selected from —O—, —S—, —NR—, —C(O)—, —C(O)O—, or is absent;\n\nn is 1; and\n
B′ is C1-C5 alkylene, C6-C12 arylene or is absent; and\n
R is selected from hydrogen, C1-C5 alkyl, C6-C12 aryl or C2-C5 acyl;\n
wherein for each instance that B and/or B′ is arylene, the substituents directly attached to the respective arylene rings (including arsenoxide), may be in a para, meta or ortho relationship, and\n
wherein each alkylene, arylene, and acyl may be independently substituted with hydrogen, C1-C5 alkyl, C2-C5 alkenyl, C2-C5 alkynyl, C3-C10 cycloalkyl, C5-C10 cycloalkenyl, C6-C12 aryl, halo, cyano, cyanate, isocyanate, OR2a, SR6, nitro, arsenoxide, —S(O)R3, —S(O)2R3, —P(O)R4R4, —N(R″)2, —NRC(O)(CH2)mQ, —C(O)R5,\n\n
wherein each R is independently selected from hydrogen, C1-C5 alkyl, C6-C12 aryl or C2-C5 acyl;\n
R2a is selected from hydrogen, C1-C5 alkyl, C6-C12 aryl, —S(O)R3, —S(O)2R3, —P(O)(R4)2 or —C(O)R5;\n
each R3 is independently selected from hydrogen, C1-C5 alkyl, C6-C12 aryl, C1-C5 alkoxy, C6-C12 aryloxy, C1-C5 alkylthio, or C6-C12 arylthio;\n
each R4 is independently selected from hydrogen, C1-C5 alkyl, C6-C12 aryl, C1-C5 alkoxy, C6-C12 aryloxy, C1-C5 alkylthio, C6-C12 arylthio, halo or N(R)2;\n
each R5 is independently selected from hydrogen, C1-C5 alkyl, C6-C12 aryl, C1-C5 alkoxy, C6-C12 aryloxy, C1-C5 alkylthio, C6-C12 arylthio, OH, SH or N(R)2;\n
R6 is selected from C1-C5 alkyl, C6-C12 aryl, C1-C5 alkylthio, C6-C12 arylthio, —S(O)R3,\n\nR″ is the same as R above;\n
Q is selected from halogen and —OS(O)2Q1; wherein Q1 is selected from C1-C4 alkyl, C1-C4 perfluoroalkyl, phenyl, p-methylphenyl; and\n
m is 1 to 5."],"number":4,"annotation":false,"title":false,"claim":true},{"lines":["The method according to claim 1, wherein\n
X is absent;\n
B is C2-C5 acyl;\n
X′ is NR;\n
n is 1;\n
B′ is phenylene; and\n
R is H;\n
wherein for each instance that B and/or B′ is arylene, the substituents directly attached to the respective arylene rings (including arsenoxide), may be in a para-, meta- or ortho-relationship."],"number":5,"annotation":false,"title":false,"claim":true},{"lines":["The method according to claim 1 wherein the compound of structural formula I is of structural Formula III:\nand wherein\n
R7 to R10 are independently selected from the group consisting of: hydrogen, C1-C5 alkyl, C6-C12 aryl, halogen, hydroxy, amino, nitro, carboxy, C1-C5 alkoxy, —OS(O)2R3 or —NHC(O)CH2Q wherein Q is halogen, —OS(O)2CH3, —OS(O)2C6H5 or —OS(O)2-p tolyl."],"number":6,"annotation":false,"title":false,"claim":true},{"lines":["The method according to claim 6, wherein R7 to R10 are independently selected from the group consisting of: hydrogen, halogen, hydroxy, amino, nitro, carboxy, C1-C5 alkoxy, methyl, ethyl, iso-propyl, tert-butyl, phenyl and —NHC(O)CH2Q wherein Q is halogen, —OS(O)2CH3, —OS(O)2C6H5 or —OS(O)2-p tolyl."],"number":7,"annotation":false,"title":false,"claim":true},{"lines":["The method according to claim 6, wherein the arsenoxide (—As═O) group is at the 4-position of the phenylene ring."],"number":8,"annotation":false,"title":false,"claim":true},{"lines":["The method according to claim 1 wherein the compound is 4-(N-(S -glutathionylacetyl)amino)phenylarsenoxide (GSAO) and is represented by Formula V:"],"number":9,"annotation":false,"title":false,"claim":true},{"lines":["The method according to claim 1 wherein the compound is represented by Formula VI:\n
wherein Q is any halogen."],"number":10,"annotation":false,"title":false,"claim":true},{"lines":["The method according to claim 1 wherein the compound is represented by Formula VII:\n
wherein G is selected from the group consisting of: hydrogen, halogen, hydroxy, amino, nitro, carboxy, C1-C5 alkoxy, C1-C5 alkyl and C6-C12 aryl and —NHC(O)CH2Q wherein Q is halogen, —OS(O)2CH3, —OS(O)2C6H5 or —OS(O)2-p tolyl."],"number":11,"annotation":false,"title":false,"claim":true},{"lines":["The method according to claim 11, wherein G is selected from the group consisting of: hydrogen, halogen, hydroxy, amino, nitro, carboxy, C1-C5 alkoxy, methyl, ethyl, iso-propyl, tert-butyl, phenyl, and —NHC(O)CH2Q wherein Q is halogen, —OS(O)2CH3, —OS(O)2C6H5 or —OS(O)2-p tolyl."],"number":12,"annotation":false,"title":false,"claim":true},{"lines":["The method according to claim 11, wherein G is selected from the group consisting of hydroxy, fluorine, amino, and nitro."],"number":13,"annotation":false,"title":false,"claim":true},{"lines":["The method according to claim 11 wherein the activity of the arsenic atom may be modified by the group G, when G and the arsenic atom are in an ortho- or para-relationship to one another."],"number":14,"annotation":false,"title":false,"claim":true},{"lines":["The method according to claim 1, wherein the arsenoxide group (—As=O) is replaced by an arsenoxide equivalent."],"number":15,"annotation":false,"title":false,"claim":true},{"lines":["The method according to claim 15, wherein said arsenoxide equivalent is in the form of -D(Z1)(Z2), wherein D is As Sn, Sb, Ge, and Z1 and Z2 are labile groups, and wherein Z1 and Z2, may be identical or different, and may either be connected or independent from each other (bound only to the arsenic atom)."],"number":16,"annotation":false,"title":false,"claim":true},{"lines":["The method according to claim 16, wherein Z1 and Z2 are selected from OH, C1-C10 alkoxy, C6-C10 aryloxy, C1-C10 alkylthio, C6-C10 arylthio, C1-C10 alkylseleno, C6-C10 arylseleno, OH, OR, SR, SeR, F, Cl, Br and I, and wherein R is an alkyl or an aryl group."],"number":17,"annotation":false,"title":false,"claim":true},{"lines":["The method according to claim 1 wherein the compound is linked to a detector group."],"number":18,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 18 wherein said detector group is selected from the group consisting of fluorophore, biotin, radionucleotide, biotin, fluorescein, and a group comprising a transition element."],"number":19,"annotation":false,"title":false,"claim":true},{"lines":["The method according to claim 18 wherein the detector group is biotin."],"number":20,"annotation":false,"title":false,"claim":true},{"lines":["The method according to claim 19 wherein the radionucleotide is selected from the group consisting of 3H, 14C, 32P, 33P, 35S, 125I, 131I, 123I, 111In, 105Rh, 153Sm, 67Cu, 67Ga, 166Ho, 177Lu, 186Re, 188Re, and 99mTc."],"number":21,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1 wherein the cancer is pancreatic or lung cancer."],"number":22,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}