{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"062-786-656-913-811","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"062-786-656-913-811"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":12121,"type":"PATENT","title":"Pusan National University Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":3630,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8626,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately:Pusan Univ*. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 3631
Search Applicants and Owners separately:Pusan Univ*. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 3631
treating cells with selenium."],"number":4,"annotation":false,"title":false,"claim":true},{"lines":["The method according to claim 4, further comprising:\n
culturing the cells in a 1 to 3% FBS-containing medium before the selenium treatment."],"number":5,"annotation":false,"title":false,"claim":true},{"lines":["The method according to claim 4, wherein the selenium is treated at a concentration of 0.1 to 20 ng/ml for 12 hours to 10 days."],"number":6,"annotation":false,"title":false,"claim":true},{"lines":["The method according to claim 4, wherein the cells are isolated from mammals."],"number":7,"annotation":false,"title":false,"claim":true},{"lines":["The method according to claim 7, wherein the cells are adipose tissue stromal cells."],"number":8,"annotation":false,"title":false,"claim":true},{"lines":["The method according to claim 7, wherein the differentiated cells exhibit an increase in expression of a stemness gene selected from the group consisting of REX1, Nanog, Oct4, Sox2, Runx3, CDK1, CDK2, Nestin, VEGF and FGFR1, compared to the differentiated cells."],"number":9,"annotation":false,"title":false,"claim":true},{"lines":["The method according to claim 7, wherein the dedifferentiated cells exhibit an increase in c-Myc expression compared to differentiated cells."],"number":10,"annotation":false,"title":false,"claim":true},{"lines":["The method according to claim 7, wherein the dedifferentiated cells exhibit an increase in telomerase activity compared to differentiated cells."],"number":11,"annotation":false,"title":false,"claim":true},{"lines":["The method according to claim 7, wherein the dedifferentiated cells exhibit a decrease in GFAP and Tuj gene expression compared to differentiated cells."],"number":12,"annotation":false,"title":false,"claim":true},{"lines":["The method according to claim 7, wherein the dedifferentiated cells exhibit a decrease in p53 and p31 expression of compared to differentiated cells."],"number":13,"annotation":false,"title":false,"claim":true},{"lines":["The method according to claim 7, wherein the dedifferentiated cells exhibit increases in PI3K gene expression, and phosphorylation for a mediator of the PI3K gene selected from the group consisting of Rac, c-Raf, MEK, ERK, Stat3 and Aid, compared to differentiated cells."],"number":14,"annotation":false,"title":false,"claim":true},{"lines":["The method according to claim 7, wherein the dedifferentiated cells exhibit a decrease in p-SAPK/JNK gene expression compared to differentiated cells."],"number":15,"annotation":false,"title":false,"claim":true},{"lines":["The method according to claim 7, wherein the dedifferentiated cells exhibit a decrease in methylation of a stemness gene selected from the group consisting of REX1, Nanog, Oct4 and Sox2, on a promoter region, compared to differentiated cells."],"number":16,"annotation":false,"title":false,"claim":true},{"lines":["The method according to claim 7, wherein the dedifferentiated cells exhibit an increase in expression of a cell migration-related gene selected from the group consisting of MMP1, MMP3, SDF1, VEGF and CXCR4, compared to differentiated cells."],"number":17,"annotation":false,"title":false,"claim":true},{"lines":["A dedifferentiated cell yielded by the method according to any one of claims 4 to 17."],"number":18,"annotation":false,"title":false,"claim":true},{"lines":["A cell therapeutic composition containing the dedifferentiated cells according to claim 18 as an active component."],"number":19,"annotation":false,"title":false,"claim":true},{"lines":["A cell redifferentiated from the dedifferentiated cell according to claim 18."],"number":20,"annotation":false,"title":false,"claim":true},{"lines":["The cell according to claim 20, wherein the redifferentiated cell is selected from the group consisting of a mesodermal cell, a neuron, an adipose cell and an insulin-producing cell."],"number":21,"annotation":false,"title":false,"claim":true},{"lines":["A cell therapeutic composition containing the redifferentiated cell according to claim 20 or 21 as an active component."],"number":22,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}