{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"062-078-049-036-530","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"062-078-049-036-530"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":11868,"type":"PATENT","title":"University of South Carolina - Columbia Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":6717,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8472,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately:Wake Forest Univ*. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 2294
Search Applicants and Owners separately:Wake Forest Univ*. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 2294
(a) an isolated flagellin adjuvant comprising:\n\n(i) a flagellin N-terminal constant region; and\n(ii) a flagellin C-terminal constant region; and\n
(b) a Yersinia pestis antigen between the flagellin N-terminal constant region and the flagellin C-terminal constant region, wherein the Y. pestis antigen comprises Y. pestis F1 antigen, Y. pestis V antigen, or a fusion peptide of Y. pestis F1 antigen and Y. pestis V. antigen; and\n
wherein the flagellin N-terminal constant region and/or the flagellin C-terminal constant region of the isolated flagellin adjuvant comprises a TLR5 recognition site and is able to activate the TLR5 pathway."],"number":1,"annotation":false,"title":false,"claim":true},{"lines":["The fusion protein of claim 1, wherein the flagellin adjuvant comprises a deleted flagellin hypervariable region or the flagellin hypervariable region is absent from the flagellin adjuvant."],"number":2,"annotation":false,"title":false,"claim":true},{"lines":["The fusion protein of claim 1, wherein the Y. pestis antigen is inserted (i) within the flagellin hypervariable region, (ii) between the flagellin N-terminal constant region and the flagellin hypervariable region, or (iii) between the flagellin C-terminal constant region and the flagellin hypervariable region."],"number":3,"annotation":false,"title":false,"claim":true},{"lines":["The fusion protein of claim 1, wherein the Yersinia pestis antigen is selected from the group consisting of Y. pestis F1 antigen, Y. pestis V antigen, and a fusion peptide of Y. pestis F1 antigen and Y. pestis V. antigen."],"number":4,"annotation":false,"title":false,"claim":true},{"lines":["An immunogenic composition comprising the fusion protein of claim 1 in a pharmaceutically acceptable carrier."],"number":5,"annotation":false,"title":false,"claim":true},{"lines":["A method of producing an immune response against\n
Yersinia pestis in a mammalian subject, the method comprising administering the fusion protein of claim 1 to the subject in an amount effective to produce the immune response in the mammalian subject against Yersinia pestis."],"number":6,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 6, wherein the administering step is carried out by delivering the fusion protein to a mucosal surface."],"number":7,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 7, wherein the administering step is carried out by intranasal or inhalation administration."],"number":8,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 6, wherein the human subject at least 50 years old."],"number":9,"annotation":false,"title":false,"claim":true},{"lines":["An immunogenic composition for mucosal administration, comprising the isolated fusion protein of claim 1 in a pharmaceutically acceptable carrier."],"number":10,"annotation":false,"title":false,"claim":true},{"lines":["The immunogenic composition of claim 10, wherein the Yersinia pestis antigen is selected from the group consisting of Y. pestis F1 antigen, Y. pestis V antigen, and a fusion peptide of Y. pestis F1 antigen and Y. pestis V. antigen."],"number":11,"annotation":false,"title":false,"claim":true},{"lines":["The immunogenic composition of claim 10, further comprising a second Yersinia pestis antigen not coupled to the flagellin adjuvant."],"number":12,"annotation":false,"title":false,"claim":true},{"lines":["A method of producing an immune response against\n
Yersinia pestis in a human subject, the method comprising mucosally administering the composition of claim 10 to the human subject in an amount effective to produce the immune response against Yersinia pestis in the human subject."],"number":13,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 13, wherein the administering step is carried out by intranasal or inhalation administration."],"number":14,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 13, wherein said subject is a human subject at least 50 years old."],"number":15,"annotation":false,"title":false,"claim":true},{"lines":["A method of producing an immune response against Yersinia pestis in a mammalian subject, the method comprising administering the immunogenic composition of claim 5 to the subject in an amount effective to produce the immune response in the mammalian subject against Yersinia pestis. "],"number":16,"annotation":false,"title":false,"claim":true},{"lines":["An isolated fusion protein comprising:\n
(a) a flagellin adjuvant comprising:\n\n(i) a flagellin N-terminal constant region; and\n(ii) a flagellin C-terminal constant region; and\n
(b) a Yersinia pestis antigen, wherein the antigen is a fusion peptide of Y. pestis F1 antigen and Y. pestis V antigen and is inserted within the flagellin hypervariable region between the flagellin N-terminal constant region and the flagellin C-terminal constant region."],"number":17,"annotation":false,"title":false,"claim":true},{"lines":["The isolated fusion protein of claim 17, wherein the fusion protein comprises the amino acid sequence of SEQ ID NO:1."],"number":18,"annotation":false,"title":false,"claim":true},{"lines":["An immunogenic composition comprising the fusion protein of claim 17 in a pharmaceutically acceptable carrier."],"number":19,"annotation":false,"title":false,"claim":true},{"lines":["A method of producing an immune response against Yersinia pestis in a mammalian subject, the method comprising administering the immunogenic composition of claim 17 to the subject in an amount effective to produce the immune response in the mammalian subject against Yersinia pestis. "],"number":20,"annotation":false,"title":false,"claim":true},{"lines":["A method of producing an immune response against Yersinia pestis in a mammalian subject, the method comprising administering the immunogenic composition of claim 19 to the subject in an amount effective to produce the immune response in the mammalian subject against Yersinia pestis. "],"number":21,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}