{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"060-464-421-907-981","frontPageModel":{"patentViewModel":{"ref":{"entityRefId":"060-464-421-907-981","entityRefType":"PATENT"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":10709,"type":"PATENT","title":"Rockefeller University Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":4213,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8226,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately: \"Rockefeller University\"; \"Univ* Rockefeller\"; \"Univ* Rockef*\"
Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 4020
Search Applicants and Owners separately: \"Rockefeller University\"; \"Univ* Rockefeller\"; \"Univ* Rockef*\"
Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 4020
Measuring gSAP (“gamma secretase activating protein”) expression for identifying whether the animal in need thereof has elevated expression levels and/or mutations in gSAP, wherein the animal in need thereof has elevated expression levels and/or mutations in gSAP relative to normal values as identified using a control population; and\n
administering to said animal an effective amount of a compound to inhibit gSAP activity,\n"],"number":1,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the accumulation of abnormal protein aggregates is related to an Aβ-mediated disease, wherein the Aβ-mediated disease is selected from the group consisting of: Alzheimer's disease, memory and cognitive disorders, dementia, amyloid neuropathies, brain inflammation, nerve and brain trauma, vascular amyloidosis, and cerebral hemorrhage with amyloidosis."],"number":2,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the mutations are one or more haplotypes selected from:\nwherein the mutations are one or more haplotypes selected from the following groups of SNPs:\n\na) rs6976567|rs1468682|rs1819814,\nb) rs1468682|rs1819814|rs4729535,\nc) rs1819814|rs4729535|rs4729540, and\nd) rs7781642|rs6955503|rs7776973,\nand wherein the compound to inhibit gSAP activity is selected from imatinib or a labeled derivative thereof, inhibitory RNA molecules capable of inhibiting gSAP expression, vectors and cells producing said inhibitory RNA molecules, antibodies to gSAP, and vaccines for gSAP.\n
c) rs1819814|rs4729535|rs4729540 and\n
d) rs7781642|rs6955503|rs7776973."],"number":3,"annotation":false,"claim":true,"title":false}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}