{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"058-127-555-586-686","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"058-127-555-586-686"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":8635,"type":"PATENT","title":"MIT Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":30193,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8198,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Select Applicants and Owners= \"MIT\", \" Massachusetts Institute of Technology \", \"Massachus* Insti* Tech*\", \"Media Lab Massachus* Insti* Tech*\", \"Massachus* Tech* Inst*\".
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Select Applicants and Owners= \"MIT\", \" Massachusetts Institute of Technology \", \"Massachus* Insti* Tech*\", \"Media Lab Massachus* Insti* Tech*\", \"Massachus* Tech* Inst*\".
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Note: over 20k
systemically administering to the subject an effective amount of 4-(acetylamino)-N-(2aminophenyl)benzamide (CI-994) or dinaline or a pharmaceutically acceptable salt."],"number":1,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the CI-994 or dinaline is administered at a dosage lower than 15 mg/m2 once a day for 14 consecutive days."],"number":2,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the CI-994 or dinaline is administered once a day for at least 2 consecutive days."],"number":3,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the CI-994 or dinaline is administered in a dose of 0.001 mg/kg to 50 mg/kg for at least 2 consecutive days."],"number":4,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the CI-994 or dinaline is administered in a dose of up to 0.4 mg/kg for at least 14 consecutive days."],"number":5,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the CI-994 or dinaline is administered in a dose of 0.001 mg/kg to 50 mg/kg for at least 2, 3, 4, 5, 6, or 7 consecutive days."],"number":6,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the CI-994 or dinaline is administered once every other day."],"number":7,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the CI-994 or dinaline is administered once a day with at least 2 days between doses."],"number":8,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the cognitive function impairments are associated with Alzheimer's disease, Huntington's disease, seizure-induced memory loss, schizophrenia, Rubinstein Taybi syndrome, Rett Syndrome, Fragile X, Lewy body dementia, vascular dementia, ADHD, dyslexia, bipolar disorder and social, cognitive and learning disorders associated with autism, traumatic head injury, or attention deficit disorder."],"number":9,"annotation":false,"title":false,"claim":true},{"lines":["A method of treating Alzheimer's disease in a subject in need thereof comprising:\n
administering to the subject an effective amount of 4-(acetylamino)-N-(2-aminophenyl)benzamide (CI-994) or dinaline or a pharmaceutically acceptable salt thereof, wherein the CI-994 or dinaline is administered at a dosage of less than 15 mg/m2 per day."],"number":10,"annotation":false,"title":false,"claim":true},{"lines":["A method of treating Alzheimer's disease in a subject in need thereof comprising:\n
systemically administering to the subject an effective amount of 4-(acetylamino)-N-(2-aminophenyl)benzamide (CI-994) or dinaline or a pharmaceutically acceptable salt thereof, wherein the CI-994 or dinaline is administered once every other day."],"number":11,"annotation":false,"title":false,"claim":true},{"lines":["A method of improving cognitive function in a normal subject comprising:\n
systemically administering to the subject an effective amount of 4-(acetylamino)-N-(2-aminophenyl)benzamide (CI-994) or dinaline or a pharmaceutically acceptable salt thereof."],"number":12,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 12, wherein the CI-994 or dinaline is administered at a dosage lower than 15 mg/m2 once a day for 14 consecutive days."],"number":13,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 12, wherein the CI-994 or dinaline is administered once every other day."],"number":14,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1 wherein\n
4-(acetylamino)-N-(2aminophenyl)benzamide (CI-994) or dinaline is administered in a dose of 0.001-50.0 mg/kg."],"number":15,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 15, wherein the CI-994 and/or dinaline is administered in a dose of 0.001 mg/kg to 15 mg/kg for at least 2 consecutive days."],"number":16,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}