{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"041-246-971-790-699","frontPageModel":{"patentViewModel":{"ref":{"entityRefId":"041-246-971-790-699","entityRefType":"PATENT"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":8902,"type":"PATENT","title":"University of Tokyo Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":20983,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8217,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search applicants and owners = \"Univ Tokyo\", \"Univ Tokyo NOT metropolitan\", \"Tokyo Univ\",\"University of Tokyo NOT metropolitan\", \"Tokyo Univ\".
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Total patent: 13934
Search applicants and owners = \"Univ Tokyo\", \"Univ Tokyo NOT metropolitan\", \"Tokyo Univ\",\"University of Tokyo NOT metropolitan\", \"Tokyo Univ\".
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Total patent: 13934
(a) detecting the expression level of NPTX1 gene in a patient-derived biological sample;
(b) comparing the detected expression level to a control level; and
(c) determining the prognosis of the patient based on the comparison of (b)."],"number":1,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the control level is a good prognosis control level and an increase of the expression level compared to the control level is determined as poor prognosis."],"number":2,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1 or 2, wherein the increase is at least 10% greater than said control level."],"number":3,"annotation":false,"claim":true,"title":false},{"lines":["The method of any one of claims 1 to 3, wherein said method comprises determining the expression level of other cancer-associated genes."],"number":4,"annotation":false,"claim":true,"title":false},{"lines":["The method of any one of claims 1 to 4, wherein said expression level is determined by any one method selected from the group consisting of:
(a) detecting mRNA of the NPTX1 gene;
(b) detecting the NPTX1 protein; and
(c) detecting the biological activity of the NPTX1 protein."],"number":5,"annotation":false,"claim":true,"title":false},{"lines":["The method of any one of claims 1 to 5, wherein said expression level is determined by detecting hybridization of a probe to a gene transcript of the NPTX1 gene."],"number":6,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 6, wherein the hybridization step is carried out on a DNA array."],"number":7,"annotation":false,"claim":true,"title":false},{"lines":["The method of any one of claims 1 to 5, wherein said expression level is determined by detecting the binding of an antibody against the NPTX1 protein as the expression level of the NPTX1 gene."],"number":8,"annotation":false,"claim":true,"title":false},{"lines":["The method of any one of claims 1 to 8, wherein said biological sample comprises a cell obtained from a lung."],"number":9,"annotation":false,"claim":true,"title":false},{"lines":["The method of any one of claims 1 to 9, wherein the cancer is lung cancer."],"number":10,"annotation":false,"claim":true,"title":false},{"lines":["A kit for assessing the prognosis of a patient with cancer, which comprises a tissue sample obtained from a patient with poor prognosis and a reagent selected from the group consisting of:
(a) a reagent for detecting mRNA of the NPTX1 gene;
(b) a reagent for detecting the NPTX1 protein; and
(c) a reagent for detecting the biological activity of the NPTX1 protein."],"number":11,"annotation":false,"claim":true,"title":false},{"lines":["The kit of claim 11, wherein the reagent is an antibody against the NPTX1 protein."],"number":12,"annotation":false,"claim":true,"title":false},{"lines":["The kit of claim 11 or 12, wherein the cancer is lung cancer."],"number":13,"annotation":false,"claim":true,"title":false}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}