{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"040-629-963-929-146","frontPageModel":{"patentViewModel":{"ref":{"entityRefId":"040-629-963-929-146","entityRefType":"PATENT"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":10778,"type":"PATENT","title":"Utrecht University - Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":1944,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8248,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately: \"Uni* Utrecht\";
Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 1024
Search Applicants and Owners separately: \"Uni* Utrecht\";
Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 1024
- incubating a GITR protein or a functional equivalent and/or a functional fragment thereof with a candidate compound
- determining whether said candidate compound binds to said GITR protein or a functional equivalent and/or a functional fragment thereof
- determining whether said candidate compound blocks or mimics an effect mediated by a GITR-GITRL interaction
- selecting a compound that blocks an effect mediated by a GITR-GITRL interaction."],"number":14,"annotation":false,"claim":true,"title":false},{"lines":["A method according to claim 14, further comprises testing said compound in a non-human animal with features reminiscent of an allergic disease."],"number":15,"annotation":false,"claim":true,"title":false},{"lines":["An isolated, recombinant or synthetic compound obtainable according to the method of claim 14 or 15."],"number":16,"annotation":false,"claim":true,"title":false},{"lines":["An isolated, recombinant or synthetic compound according to claim 16, wherein said compound is a proteinaceous substance."],"number":17,"annotation":false,"claim":true,"title":false},{"lines":["An isolated, recombinant or synthetic compound according to claim 17, wherein said proteinaceous substance is an antibody or a functional equivalent and/or a functional fragment thereof."],"number":18,"annotation":false,"claim":true,"title":false},{"lines":["A nucleic acid encoding a compound according to claim 17 or 18."],"number":19,"annotation":false,"claim":true,"title":false},{"lines":["A vector comprising a nucleic acid according to claim 19."],"number":20,"annotation":false,"claim":true,"title":false},{"lines":["A gene delivery vehicle comprising a vector according to claims 20."],"number":21,"annotation":false,"claim":true,"title":false},{"lines":["A pharmaceutical composition comprising an isolated, recombinant or synthetic compound according to anyone of claims 16 to 18, a nucleic acid according to claim 19, a vector according to claim 20 or a gene delivery vehicle according to claim 21."],"number":22,"annotation":false,"claim":true,"title":false},{"lines":["A pharmaceutical composition according to claim 22, further comprising an allergen."],"number":23,"annotation":false,"claim":true,"title":false},{"lines":["A pharmaceutical composition according to claim 23, wherein said allergen is an allergen involved in allergic disease."],"number":24,"annotation":false,"claim":true,"title":false},{"lines":["A pharmaceutical composition according to claim 24, wherein said allergic disease is asthma."],"number":25,"annotation":false,"claim":true,"title":false},{"lines":["Use of an isolated, recombinant or synthetic compound according to anyone of claims 16 to 18, a nucleic acid according to claim 19, a vector according to claim 20 or a gene delivery vehicle according to claim 21 for the preparation of a medicament for the treatment of an allergy."],"number":26,"annotation":false,"claim":true,"title":false},{"lines":["Use according to claim 26 wherein said compound is an inhibitor of GITR or wherein said compound at least in part inhibits the expression of GITR or wherein said compound is an inhibitor of a GITRL or wherein said compound at least in part inhibits the expression of GITRL."],"number":27,"annotation":false,"claim":true,"title":false},{"lines":["Use according to claim 26 or 27, wherein said allergy is asthma."],"number":28,"annotation":false,"claim":true,"title":false},{"lines":["A method according to any one of claims 1 to 13, further comprising providing said subject with a compound capable of activating a CTLA4 receptor."],"number":29,"annotation":false,"claim":true,"title":false},{"lines":["A method for suppressing GITR activation of cells expressing said GITR, comprising providing, in the presence of an allergen, said cells with an inhibitor of GITR."],"number":30,"annotation":false,"claim":true,"title":false}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}