{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"038-416-638-419-379","frontPageModel":{"patentViewModel":{"ref":{"entityRefId":"038-416-638-419-379","entityRefType":"PATENT"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":11852,"type":"PATENT","title":"University of Mainz Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":15149,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8464,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately:univ* AND Mainz. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 1203
Search Applicants and Owners separately:univ* AND Mainz. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 1203
(1) an immediate release first dosage composition in the form of compressed minitablets, the immediate release first dosage composition comprising an antibiotic; and\n
(2) a delayed release second dosage composition in the form of compressed minitablets, the delayed release second dosage composition comprising a proton pump inhibitor and a coating, wherein, when tested in a basket apparatus, the delayed release second dosage composition meets the two stage test dissolution profile in a basket apparatus: (a) release of not more than 10% by weight of the proton pump inhibitor in 120 min in an acid stage comprising 900 ml 0.1N HCl at 100 rpm; and (b) release of not less than 75% by weight of the proton pump inhibitor in 45 min in 900 ml phosphate buffer pH 6.8 at 100 rpm following the acid stage."],"number":1,"annotation":false,"claim":true,"title":false},{"lines":["The capsule of claim 1 wherein the coating in the second dosage composition delays the release of the proton pump inhibitor from 120 to at least 240 minutes following oral administration."],"number":2,"annotation":false,"claim":true,"title":false},{"lines":["The capsule of claim 1 wherein the first dosage composition comprises amoxicillin."],"number":3,"annotation":false,"claim":true,"title":false},{"lines":["The capsule of claim 1 wherein, in the second dosage composition, the proton pump inhibitor is one of omeprazole, pantoprazole, lansoprazole, ilaprazole, dexlansoprazole, esomeprazole or rabeprazole, pharmaceutically acceptable salt or solvates thereof or combinations thereof."],"number":4,"annotation":false,"claim":true,"title":false},{"lines":["The capsule of claim 1 wherein the second dosage composition comprises a time delay agent."],"number":5,"annotation":false,"claim":true,"title":false},{"lines":["The capsule of claim 5 wherein the time delay agent is one of sodium alginate, glyceryl monostearate, glyceryl distearate, acrylic acids, celluloses or combinations thereof."],"number":6,"annotation":false,"claim":true,"title":false},{"lines":["The capsule of claim 1 wherein at least 70% by weight of the antibiotic is released between 5 and 120 minutes following oral administration; and at least 70% by weight of the proton pump inhibitor is released between 120 and 240 min following oral administration."],"number":7,"annotation":false,"claim":true,"title":false},{"lines":["The capsule of claim 1 comprising amoxicillin and omeprazole."],"number":8,"annotation":false,"claim":true,"title":false},{"lines":["The capsule of claim 8 wherein the amoxicillin to omeprazole ratio ranges from 20 to 40 by weight."],"number":9,"annotation":false,"claim":true,"title":false},{"lines":["The capsule claim 1, wherein the first and second dosage compositions further comprise a filler, a disintegrant, a binder, a surfactant, an alkalizing agent, a lubricant or combinations thereof."],"number":10,"annotation":false,"claim":true,"title":false},{"lines":["The capsule of claim 10 wherein the filler is one of lactose, cellulose, starch, calcium phosphates, calcium carbonate, sugar, or combinations thereof."],"number":11,"annotation":false,"claim":true,"title":false},{"lines":["The capsule of claim 10 wherein the disintegrant is one of croscarmellose sodium, carboxymethyl cellulose, sodium starch glycolate, crospovidone or combinations thereof."],"number":12,"annotation":false,"claim":true,"title":false},{"lines":["The capsule of claim 10 wherein the binder is one of starch, cellulose, polyvinylpyrrolidone, xanthan gum, alginic acid, agar or combinations thereof."],"number":13,"annotation":false,"claim":true,"title":false},{"lines":["The capsule of claim 10 wherein the surfactant is one of sodium lauryl sulphate, polyoxyethylene polyoxypropylene glycol, polyethylene glycol, poplypropylene glycol, polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol, macrogolglycerol hydroxystearate or combinations thereof."],"number":14,"annotation":false,"claim":true,"title":false},{"lines":["The capsule of claim 10 wherein the alkalizing agent is one of meglumine, calcium carbonate, sodium sulfate, sodium bicarbonate or combinations thereof."],"number":15,"annotation":false,"claim":true,"title":false},{"lines":["The capsule of claim 10 wherein the lubricant is one of magnesium stearate, silicon dioxide, talc, stearic acid, sodium stearyl fumarate, glyceryl behenate or combinations thereof."],"number":16,"annotation":false,"claim":true,"title":false},{"lines":["The capsule of claim 1 wherein the first dosage composition comprises 250 mg amoxicillin and wherein the second dosage composition comprises 10 mg omeprazole, derivatives thereof, or pharmaceutically acceptable salts or solvates thereof."],"number":17,"annotation":false,"claim":true,"title":false},{"lines":["The capsule of claim 1, wherein the second dosage composition comprises an outer protective layer, an enteric coating and an inner protective layer."],"number":18,"annotation":false,"claim":true,"title":false},{"lines":["A method for treating H. pylori in a host comprising administering to a host the capsule of claim 1 three times a day."],"number":19,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 19 comprising treating a host for at least 14 days and wherein the treatment results in an eradication rate greater than 84%."],"number":20,"annotation":false,"claim":true,"title":false}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}