{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"030-585-404-982-587","frontPageModel":{"patentViewModel":{"ref":{"entityRefId":"030-585-404-982-587","entityRefType":"PATENT"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":8759,"type":"PATENT","title":"University of Columbia","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":13487,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8203,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Searched applicants and Owners= \"Columbia Univ\", \"Univ Columbia\", \" Univ Colum*\", \"Colum* univ\", \"Univ* Colum* NOT British\".
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Total patents: more than 10k
Searched applicants and Owners= \"Columbia Univ\", \"Univ Columbia\", \" Univ Colum*\", \"Colum* univ\", \"Univ* Colum* NOT British\".
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Total patents: more than 10k
providing the isolated mammalian cells, the biomaterial matrix and the core material;\n
contacting the mammalian cells and the biomaterial matrix;\n
contacting the biomaterial matrix and the core material;\n
forming a plurality of macrochannels in the biomaterial matrix, the plurality of macrochannels not exposing the core material underlying the biomaterial matrix; and\n
incubating the biomaterial matrix, the mammalian cells, and the core material to form the hybrid soft tissue construct;\n
wherein,\n
the biomaterial matrix is a polyethylene glycol diacrylate (PEGDA) hydrogel further comprising the mammalian cells;\n
the hydrogel with the mammalian cells are contacted with the core material as a liquid then photopolymerized into a gel;\n
formation of the macrochannels comprises placing capillary tubes radially at locations near the core material before the core material and the hydrogel with the mammalian cells are contacted;\n
each of the capillary tubes is removed after the hydrogel with the mammalian cells contact the core material and after the hydrogel photopolymerizes into the gel;\n
the core material is acellular and biocompatible, and designed to remain acellular upon implantation in a subject;\n
the biomaterial matrix comprises a plurality of microchannel pores throughout the biomaterial matrix;\n
the plurality of macrochannels have an average diameter of 0.1 mm to 50 mm;\n
the plurality of macrochannels does not expose the core material to host tissue; and\n
the biomaterial matrix contacts and covers the acellular core."],"number":1,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the mammalian cells comprise adipose cells, interstitial cells, endothelial cells, smooth muscle cells, progenitor cells thereof, or a combination thereof."],"number":2,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the mammalian cells comprise (i) adipose cells, (ii) progenitor cells selected from the group consisting of adipose tissue derived cells, pre-adipocytes, mesenchymal stem cells (MSC), MSC-derived cells, and adipocytes, or (iii) a combination thereof."],"number":3,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the construct is a soft tissue implant for a breast, a face or a hand."],"number":4,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the construct is a breast implant."],"number":5,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the core material is (i) a saline or silicone gel implant, or (ii) a solid, high-cohesive, form-stable implant."],"number":6,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the plurality of macrochannels have an average diameter of 2.5 mm to 50 mm."],"number":7,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the biomaterial matrix comprises a growth factor selected from the group consisting of bFGF, VEGF and PDGF."],"number":8,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the mammalian cells are present in the biomaterial matrix at a density of 0.0001×106 cells ml−1 to 1000×106 cells ml−1."],"number":9,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the mammalian cells comprise a first progenitor cell and a second progenitor cell, the first progenitor cell is an adipose progenitor cell, and the second progenitor cell is a vascular progenitor cell."],"number":10,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein a layer comprising isolated adipose cells covers the core material."],"number":11,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein incubation occurs in vitro."],"number":12,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein incubation occurs in vivo."],"number":13,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein incubation occurs in vitro and in vivo."],"number":14,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the acellular core material has a volume of 0.5 cm3 to 100 cm3."],"number":15,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, the core material is selected from the group consisting of an artificial implant material, a breast implant material, a saline implant, a silicone gel implant, a multiple lumen design implant, a gummy bear implant, a solid implant, a high-cohesive implant, and a form-stable implant; and\n
the core material is suitable to be functionalized by surrounding autologous engineered adipose tissue from progenitor cells."],"number":16,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, further comprising coating the core material with an elastomer or polyurethane foam."],"number":17,"annotation":false,"claim":true,"title":false}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}