{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"028-289-827-786-950","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"028-289-827-786-950"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":10731,"type":"PATENT","title":"The University of North Carolina at Chapel Hill - Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":8887,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8232,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately:\"uni* north caro*\". Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 1000
Search Applicants and Owners separately:\"uni* north caro*\". Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 1000
(a) M1, wherein M1 is a multivalent metal ion; and\n
(b) a bisphosphonate, wherein the bisphosphonate comprises a metal complex having the formula M2Lx-2[O—C(═O)—NH—P(═O)(OR)2]2, wherein x is an integer of 2 or greater, M2 is a platinum ion, each L is a monodentate or bidentate ligand, and wherein each R is independently H, alkyl, substituted alkyl, aralkyl, aryl, substituted aryl, or a negative charge."],"number":1,"annotation":false,"title":false,"claim":true},{"lines":["The metal-bisphosphonate nanoparticle of claim 1, wherein each R is independently H, alkyl, or a negative charge."],"number":2,"annotation":false,"title":false,"claim":true},{"lines":["The metal-bisphosphonate nanoparticle of claim 1, wherein the nanoparticle further comprises one or more coating agents or layers surrounding at least a portion of an outer surface of the core."],"number":3,"annotation":false,"title":false,"claim":true},{"lines":["The metal bisphosphonate nanoparticle of claim 3, wherein the one or more coating agents or layers comprise at least one lipid coating layer or agent."],"number":4,"annotation":false,"title":false,"claim":true},{"lines":["The metal-bisphosphonate nanoparticle of claim 1, further comprising a non-bisphosphonate therapeutic agent or prodrug thereof and/or an imaging agent."],"number":5,"annotation":false,"title":false,"claim":true},{"lines":["A pharmaceutical composition comprising a metal-bisphosphonate nanoparticle of claim 1; and a pharmaceutically acceptable carrier."],"number":6,"annotation":false,"title":false,"claim":true},{"lines":["A method of treating a cancer or a bone related disorder selected from the group consisting of osteoporosis and Paget's disease in a subject in need of treatment thereof, wherein the method comprises administering to the subject an effective amount of a metal-bisphosphonate nanoparticle of claim 1."],"number":7,"annotation":false,"title":false,"claim":true},{"lines":["The metal-bisphosphonate nanoparticle of claim 5, wherein the non-bisphosphonate therapeutic agent is a small interfering RNA."],"number":8,"annotation":false,"title":false,"claim":true},{"lines":["The metal-bisphosphonate nanoparticle of claim 1, wherein M1 is Zn2+."],"number":9,"annotation":false,"title":false,"claim":true},{"lines":["The metal-bisphosphonate nanoparticle of claim 1, wherein x is 5 or 6 and wherein each L is independently selected from the group consisting of CI, Br, F, I, NH3, alkylamino, alkoxy, hydroxyl, diol, and diamine."],"number":10,"annotation":false,"title":false,"claim":true},{"lines":["The metal-bisphosphonate nanoparticle of claim 1, wherein M1 is Zn2+, x is 6, each L is selected from halo and NH3, and wherein each R is H, alkyl or a negative charge."],"number":11,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}