{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"019-700-934-673-151","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"019-700-934-673-151"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":11683,"type":"PATENT","title":"Cardiff University - Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":2576,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8339,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
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R1 is selected from the group consisting of C1-C24 alkyl, C1-C24 alkenyl, and C1-C24 alkynyl;\n
R2, R3, R7, and R8 are each independently selected from the group consisting of hydrogen, NO2, OH, and OOH, wherein at least one of R2, R3, R7, and R8 is NO2;\n
R4 is C1-C24 alkyl, C1-C24 alkenyl, or C1-C24 alkynyl, wherein R4 comprises a terminal COOR6 and R6 is hydrogen, C1-C24 alkyl, or a pharmaceutically acceptable counterion;\n
R5 is hydrogen or R4 and R5 collectively form ═C(R9)(R10), wherein R9 is C1-C24 alkyl, C1-C24 alkenyl, or C1-C24 alkynyl and R10 is hydrogen, NO2, OH, or OOH; and\n
n is from 1 to 24, and a therapeutic agent."],"number":1,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the therapeutic agent is selected from a group consisting of antibodies, antivirals, steroidal and non-steroidal anti-inflammatories, conventional immunotherapeutic agents, cytokines, chemokines, and growth factors."],"number":2,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the lipid comprises a fatty acid."],"number":3,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the lipid is selected from the group consisting of glycolipids, glycerolipids, phospholipids, and cholesterol."],"number":4,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the lipid is selected from the group consisting of oleic acid (18:1), 22:6, and docosahexanoic acid."],"number":5,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the lipid comprises 10-nitro-9-cis,12-cis-octadecadienoic acid."],"number":6,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the lipid is selected from the group consisting of linoleic acid (18:2), linolenic acid (18:3), and cholesterol linoleate."],"number":7,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the lipid comprises arachidonic acid (20:4)."],"number":8,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, the lipid having the formula:\nwherein:\n
R9 is C1-C24 alkyl, C1-C24 alkenyl, or C1-C24 alkynyl and includes a terminal COOR6; and\n
R10 is hydrogen, NO2, OH, or OOH,\n
wherein at least one of R2, R3, R7, R8, and R10 is NO2."],"number":9,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein R1 is C4-C10 alkyl; R2, R8, and R10 are hydrogen; R7 is NO2; and R9 is C6-C12 alkyl."],"number":10,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein R3 and R8 are cis to one another, and R7 and R10 are cis to one another."],"number":11,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein R1 is C4-C10 alkyl; R2, R3, and R7 are hydrogen; R8 is NO2; and R4 is C6-C12 alkyl."],"number":12,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the lipid comprises 12-nitro-9-cis,12-cis-octadecadienoic acid."],"number":13,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein R9 is C6-C12 alkyl."],"number":14,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the lipid is 10-nitro-9-cis-octadecaenoic acid."],"number":15,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the lipid and the therapeutic agent are administered from a group consisting of concomitantly, simultaneously, and sequentially."],"number":16,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the lipid and the therapeutic agent are administered selected from a group consisting of topically, orally, by inhalation, parenterally, intravenously, intraperitoneally, intramuscularly, subcutaneously, intracavity, transdermally, intratracheally, and extracorporeally."],"number":17,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the vascular disease is selected from a group consisting of cardiomyopathy, hypertension, atherosclerosis, myocardial infarction, peripheral vascular disease, coronary artery disease, heart failure and stroke."],"number":18,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}