{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"018-802-963-780-854","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"018-802-963-780-854"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":11697,"type":"PATENT","title":"Oregon Health and Science University - Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":2948,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8352,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
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contacting a biological sample from the subject, wherein the biological sample comprises T cells, with one or more isolated Mycobacterium polypeptide, wherein one of the isolated Mycobacterium polypeptides comprises the amino acid sequence set forth as SEQ ID NO: 8[, SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7, SEQ ID NO: 8, SEQ ID NO: 9, SEQ ID NO: 11 or SEQ ID NO: 12]; and\n
determining if the T cells specifically recognize the Mycobacterium polypeptide, wherein the presence of T cells that specifically recognize the Mycobacterium polypeptide detects Mycobacterium tuberculosis in the subject."],"number":1,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the isolated Mycobacterium polypeptide consists of the amino acid sequence set forth as SEQ ID NO: 8."],"number":2,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the T cells are CD8+T cells."],"number":3,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 3, in which determining if the CD8+T cells specifically recognize the Mycobacterium polypeptide comprises\n
measuring secretion of a cytokine from the CD8+T cells, thereby determining if the CD8+T cells specifically recognize the Mycobacterium polypeptide."],"number":4,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 4, wherein the cytokine is interferon (IFN)-γ."],"number":5,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 5, wherein measuring secretion of IFN-γ comprises use of an antibody that specifically binds IFN-γ."],"number":6,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the biological sample is blood, isolated peripheral blood mononuclear cells, or isolated mononuclear cells."],"number":7,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the T cells are cultured in vitro with the Mycobacterium polypeptide."],"number":8,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the biological sample is isolated T cells."],"number":9,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 9, wherein the isolated T cells are cultured in vitro prior to contacting the biological sample with the isolated Mycobacterium polypeptide comprising the amino acid sequence set forth as SEQ ID NO: 8[, SEQ ID NO: 7, SEQ ID NO: 12, SEQ ID NO: 11, SEQ ID NO: 9, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, or SEQ ID NO: 1]."],"number":10,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 9, wherein the T cells are cultured in vitro with antigen presenting cells."],"number":11,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 4, wherein the isolated Mycobacterium polypeptide consists of the amino acid sequence set forth as SEQ ID NO: 8."],"number":12,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}