{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"015-567-891-741-031","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"015-567-891-741-031"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":11616,"type":"PATENT","title":"Case Western Reserve University - Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":4001,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8291,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately: weste* reser* AND Univ*
Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 2737
Search Applicants and Owners separately: weste* reser* AND Univ*
Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 2737
obtaining a bodily sample from the subject, the bodily sample comprising a bodily fluid selected from the group consisting of blood, plasma, sera, and urine,\n
combining the bodily sample with at least one reaction solution for generating H2O2 upon combination with AMACR in the bodily sample, the reaction solution including a (2R)-2-methylacyl-CoA epimer that can be chirally inverted by AMACR to a (2S)-2-methylacyl-CoA epimer and an enzyme that carries out beta oxidation with the (2S)-2-methylacyl-CoA epimer to generate hydrogen peroxide (H2O2); and\n
detecting the amount of H2O2 generated in the reaction solution with a biosensor, wherein increased amount of H2O2 detected compared to a control is indicative of an increased amount of AMACR in the bodily sample."],"number":1,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, the reaction solution including coenzyme A (CoA), peroxisomalacyl-coenzyme A oxidase 3 (ACOX3), adensonsine triphosphate (ATP), and a branched fatty acid with (R) and (S) epimers of which only the (R) epimer is a reaction substrate for AMACR."],"number":2,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 2 the branched fatty acid comprising pristanic acid."],"number":3,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, the biosensor including a working electrode and a counter electrode, the working electrode and counter electrode including catalyst particles for increasing the rate of electrochemical oxidation-reduction reaction with H2O2 and providing the detection of H2O2 at a lower oxidation potential than without the presence of the catalyst particles."],"number":4,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 4, the catalyst particles comprising nano-particle metallic catalysts."],"number":5,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 4, the catalyst particles comprising a unary metal (M), a binary metal (M-X), a unary metal oxide (MOy), a binary metal oxide (MOy-XOy), a metal-metal oxide composite material (M-MOy) or a combination of which, wherein y is less than 3, and M and X are independently selected from a group consisting of Li, Na, Mg, Al, K, Ca, Cr, Mn, Fe, Co, Ni, Cu, Zn, Ga, Sr, Y, Zr, Nb, Mo, Ru, Rh, Pd, Ag, Cd, In, Sn, Ba, La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Lu, Ta, W, Os, Ir, Pt, Au, and Pb."],"number":6,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 4, the catalyst particles comprising iridium oxide particles."],"number":7,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 4, further comprising applying voltage potentials to the working electrode and counter electrode and measuring the current flow between the working electrode and counter electrode to determine the level of H2O2."],"number":8,"annotation":false,"title":false,"claim":true},{"lines":["A method of detecting prostate cancer or an increased risk of prostate cancer in a subject, the method comprising:\n
obtaining a bodily sample from the subject, the bodily sample comprising a bodily fluid selected from the group consisting of blood, plasma, sera, and urine,\n
combining the bodily sample with at least one reaction solution for generating H2O2 upon combination with alpha-methylacyl-CoA racemase (AMACR) in the bodily sample, the reaction solution including a (2R)-2-methylacyl-CoA epimer that can be chirally inverted by AMACR to a (2S)-2-methylacyl-CoA epimer and an enzyme that carries out beta oxidation with the (2S)-2-methylacyl-CoA epimer to generate hydrogen peroxide (H2O2); and\n
detecting the amount of H2O2 generated in the reaction solution with a biosensor, wherein increased amount of H2O2 detected compared to a control is indicative of the subject having prostate cancer or an increased risk of prostate cancer."],"number":9,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 9, the reaction solution including coenzyme A (CoA), peroxisomalacyl-coenzyme A oxidase 3 (ACOX3), adensonsine triphosphate (ATP), and a branched fatty acid with (R) and (S) epimers of which only the (R) epimer is a reaction substrate for AMACR."],"number":10,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 10, the branched fatty acid comprising pristanic acid."],"number":11,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 9, the biosensor including a working electrode and a counter electrode, the working electrode and counter electrode including catalyst particles for increasing the rate of electrochemical oxidation-reduction reaction with H2O2 and providing the detection of H2O2 at a lower oxidation potential than without the presence of the catalyst particles."],"number":12,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 12, the catalyst particles comprising nano-particle metallic catalysts."],"number":13,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 12, the catalyst particles comprising a unary metal (M), a binary metal (M-X), a unary metal oxide (MOy), a binary metal oxide (MOy-XOy), a metal-metal oxide composite material (M-MOy) or a combination of which, wherein y is less than 3, and M and X are independently selected from a group consisting of Li, Na, Mg, Al, K, Ca, Cr, Mn, Fe, Co, Ni, Cu, Zn, Ga, Sr, Y, Zr, Nb, Mo, Ru, Rh, Pd, Ag, Cd, In, Sn, Ba, La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Lu, Ta, W, Os, Ir, Pt, Au, and Pb."],"number":14,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 12, the catalyst particles comprising iridium oxide particles."],"number":15,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 12, further comprising applying voltage potentials to the working electrode and counter electrode and measuring the current flow between the working electrode and counter electrode to determine the level of H2O2."],"number":16,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}