{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"015-255-899-333-46X","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"015-255-899-333-46X"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":11855,"type":"PATENT","title":"University of Montpellier Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":11808,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8467,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately:univ* AND Montpellier. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 1289
Search Applicants and Owners separately:univ* AND Montpellier. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 1289
(a) said first protein being selected from the group consisting of
(i) MAP17 (SEQ ID NO:1),
(ii) a MAP17 homologue having an amino acid sequence at least 90% identity to that of MAP17 (SEQ ID NO:1) and capable of interacting with SCAMP2 (SEQ ID NO:2),
(iii) a MAP17 fragment of MAP17 (SEQ ID NO:1) capable of interacting with SCAMP2 (SEQ ID NO:2), and
(iv) a fusion protein containing MAP17 (SEQ ID NO:1), said MAP17 homologue or said MAP17 fragment; and
(b) said second protein being selected from the group consisting of
(1) SCAMP2 (SEQ ID NO:2),
(2) a SCAMP2 homologue having an amino acid sequence at least 90% identity to that of SCAMP2 (SEQ ID NO:2) and capable of interacting with MAP17 (SEQ ID NO:1),
(3) a SCAMP2 fragment of SCAMP2 (SEQ ID NO:2) capable of interacting with MAP17 (SEQ ID NO:1), and
(4) a fusion protein containing SCAMP2 (SEQ ID NO:2), said SCAMP2 homologue or said SCAMP2 fragment, said method comprising:
contacting said first protein with said second protein in the presence of a test compound; and
detecting the interaction between said first protein and said second protein; and
selecting a test compound that modulates the interaction between a first protein and a second protein."],"number":1,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1 , wherein at least one of said first and second proteins is a fusion protein having a detectable tag."],"number":2,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1 , wherein said contacting step is conducted in vitro."],"number":3,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1 , wherein the interaction between said first protein and said second protein is determined in a host cell."],"number":4,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 4 , wherein said host cell is a yeast cell."],"number":5,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1 , wherein said detecting step comprises measuring the amount of the protein complex formed by said first and second proteins."],"number":6,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1 , further comprising a step of generating a data set defining one or more selected test compounds, said data set being embodied in a transmittable form."],"number":7,"annotation":false,"title":false,"claim":true},{"lines":["A method for selecting compounds capable of interfering with the interaction between a first protein and a second protein, wherein
(a) said first protein is selected from the group consisting of
(i) MAP17 (SEQ ID NO:1),
(ii) a MAP17 homologue having an amino acid sequence at least 90% identity to that of MAP17 (SEQ ID NO:1 and capable of interacting with SCAMP2 (SEQ ID NO:2),
(iii) a MAP17 fragment of MAP17 (SEQ ID NO:1) capable of interacting with SCAMP2 (SEQ ID NO:2), and
(iv) a fusion protein containing MAP17 (SEQ ID NO:1), said MAP17 homologue or said MAP17 fragment; and
(b) said second protein is selected from the group consisting of
(1) SCAMP2 (SEQ ID NO:2),
(2) a SCAMP2 homologue having an amino acid sequence at least 90 % identity to that of SCAMP2 (SEQ ID NO:2) and capable of interacting with MAP17 (SEQ ID NO:1),
(3) a SCAMP2 fragment of SCAMP2 (SEQ ID NO:2) capable of interacting with MAP17 (SEQ ID NO:1), and
(4) a fusion protein containing SCAMP2 (SEQ ID NO:2), said SCAMP2 homologue or said SCAMP2 fragment, said method comprising:
contacting said first protein with said second protein in the presence of a test compound and detecting the interaction between said first protein and said second protein; and
contacting said first protein with said second protein in the absence of said test compound and detecting the interaction between said first protein and said second protein; and
selecting a compound that interferes the interaction between a first protein and a second protein."],"number":8,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 8 , wherein said contacting steps are conducted in vitro."],"number":9,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 8 , wherein said contacting steps are conducted in a host cell."],"number":10,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 8 , wherein the first protein is a fusion protein containing MAP17 (SEQ ID NO:1), said MAP17 homologue or said MAP17 fragment of MAP17 (SEQ ID NO:1), and said second protein is a fusion protein containing SCAMP2 (SEQ ID NO:2), said SCAMP2 homologue or said SCAMP2 fragment of SCAMP2 (SEQ ID NO:2)."],"number":11,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 8 , further comprising a step of generating a data set defining one or more selected test compounds, said data set being embodied in a transmittable form."],"number":12,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}