{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"010-110-434-171-254","frontPageModel":{"patentViewModel":{"ref":{"entityRefId":"010-110-434-171-254","entityRefType":"PATENT"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":11993,"type":"PATENT","title":"University of Connecticut Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":3197,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8558,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately:Univ* Connecti*. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 2880
Search Applicants and Owners separately:Univ* Connecti*. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 2880
obtaining a tumor polypeptide set from a tumor sample;\n
identifying polypeptides present in the tumor sample by comparing the tumor polypeptide set with a reference polypeptide set;\n
obtaining known mutant polypeptides for each identified tumor polypeptide from a mutant polypeptide set; and\n
identifying tumor-specific polypeptides by combining the tumor polypeptide set and the known mutant polypeptides and removing wild-type polypeptides."],"number":1,"annotation":false,"claim":true,"title":false},{"lines":[") The method of claim 1, further comprising:\n
obtaining mass spectra for one or more of the polypeptides; and\n
identifying the one or more polypeptides by the mass spectra."],"number":2,"annotation":false,"claim":true,"title":false},{"lines":[") The method of claim 1, farther comprising:\n
obtaining a sample mass spectra library of polypeptides from a tumor sample; and\n
generating the tumor polypeptide set by converting the mass spectra library to a set of tumor polypeptide sequences."],"number":3,"annotation":false,"claim":true,"title":false},{"lines":[") The method of claim 1, further comprising:\n
obtaining a gene mutation set from the tumor sample; and\n
generating the tumor polypeptide set by translating the DNA in the gene mutation set to amino acid sequences."],"number":4,"annotation":false,"claim":true,"title":false},{"lines":[") The method of claim 1 further comprising:\n
identifying tumor-specific polypeptides by identifying the polypeptides that are present in both the tumor polypeptide set and the blown mutant polypeptides."],"number":5,"annotation":false,"claim":true,"title":false},{"lines":[") The method of claim 3 further comprising:\n
obtaining a tumor-specific mass spectra library from the tumor-specific polypeptides; and\n
comparing the sample mass spectra library and the tumor-specific mass spectra library; and\n
identifying additional tumor-specific polypeptides by identifying polypeptides present in the sample mass spectra library and the tumor-specific mass spectra library."],"number":6,"annotation":false,"claim":true,"title":false},{"lines":[") The method of claim 4, further comprising:\n
obtaining the DNA sequences of the tumor-specific polypeptides from a reference database; and\n
identifying DNA sequences present in both the gene mutation set and the DNA sequences of the tumor-specific polypeptides; and\n
identifying additional tumor-specific polypeptides by translating the shared sequences to amino acid sequences."],"number":7,"annotation":false,"claim":true,"title":false},{"lines":[") A method for selecting a treatment strategy in a patient, comprising:\n
generating a patient tumor polypeptide signature comprising identifying polypeptides specific for a patient's tumor sample according to claim 1;\n
obtaining a control tumor polypeptide signature from one or more other patients who have been favorably treated;\n
comparing the patient tumor polypeptide signature with the control tumor polypeptide signatures;\n
determining the similarity of the signatures;\n
selecting a treatment strategy that produced a favorable outcome in the other patient if the signatures are similar."],"number":8,"annotation":false,"claim":true,"title":false},{"lines":[") A polypeptide comprising or consisting of one or more of the amino acid sequences according to SEQ. ID. Nos. 1-23."],"number":9,"annotation":false,"claim":true,"title":false},{"lines":[") A binding molecule, which selectively binds to at least one of the polypeptides identified as SEQ. ID. Nos. 1-23."],"number":10,"annotation":false,"claim":true,"title":false},{"lines":[") A method for increasing a patient's immune response to tumor cells, the method comprising administering one or more of the polypeptides identified as SEQ. ID. No. 1-23 to a patient."],"number":11,"annotation":false,"claim":true,"title":false},{"lines":[") The method of claim 31, wherein the polypeptides are administered prior to traditional cancer immunotherapy to enhance efficacy of the immunotherapy."],"number":12,"annotation":false,"claim":true,"title":false},{"lines":[") A composition for targeting therapeutic agents to a tumor, comprising the binding molecule of claim 10 and a therapeutic agent, wherein the binding molecule is conjugated to the therapeutic agent."],"number":13,"annotation":false,"claim":true,"title":false},{"lines":[") A method for targeting therapeutic agents to a tumor, comprising administering the composition of claim 13 to a patient with a tumor."],"number":14,"annotation":false,"claim":true,"title":false},{"lines":[") A composition for detecting tumors, the method comprising the binding molecule of claim 10 and a detectable label, wherein the binding molecule is conjugated to the detectable label."],"number":15,"annotation":false,"claim":true,"title":false},{"lines":[") A method of targeting a detectable label to a tumor, comprising administering the composition of claim 15 to a patient."],"number":16,"annotation":false,"claim":true,"title":false},{"lines":[") An array comprising a polypeptide set, the set consisting of one or more tumor-specific polypeptides identified by the method according to claim 1."],"number":17,"annotation":false,"claim":true,"title":false},{"lines":[") A method of generating antigen-HLA receptor complexes, comprising:\n
identifying tumor-specific polypeptides according to claim 1;\n
selecting tumor-specific polypeptides that bind to one or more HLA receptors;\n
obtaining recombinant tumor-specific polypeptides; and\n
conjugating the recombinant tumor-specific polypeptides with one or more HLA receptors."],"number":18,"annotation":false,"claim":true,"title":false},{"lines":[") A method of treating cancer comprising:\n
obtaining a sample from a cancer patient;\n
sorting cells in the patient sample with one or more of the antigen-HLA receptor complexes generated according to the method of claim 18;\n
identifying cancer-specific T-cells in the sample;\n
growing the cancer-specific T-cells in cell culture; and\n
administering the cancer-specific T cells to the cancer patient."],"number":19,"annotation":false,"claim":true,"title":false},{"lines":[") A method for generating a DNA vaccine comprising:\n
identifying tumor-specific polypeptides according to claim 1;\n
identifying the antigenic regions of the tumor-specific polypeptides;\n
obtaining nucleotide sequences that encode for a peptide that targets the antigenic regions of the tumor-specific polypeptides; and\n
preparing the DNA sequences as a vector."],"number":20,"annotation":false,"claim":true,"title":false}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}