{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"005-007-869-456-412","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"005-007-869-456-412"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":8838,"type":"PATENT","title":"Univ of Illinois Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":10245,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8209,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately = \"Univ Illinois\", \"Illinois Univ\", \"University of Illinois\", \"Illinois University\", \"University Illinois NOT Northern NOT southern NOT State\".
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Total patents: 9630
Search Applicants and Owners separately: uni* illinois chicago
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Add to collection. Total patents: 4560
Search Applicants and Owners separately: univ* AND Kansas. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 1781
Search Applicants and Owners separately = \"Univ Illinois\", \"Illinois Univ\", \"University of Illinois\", \"Illinois University\", \"University Illinois NOT Northern NOT southern NOT State\".
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Add the result to Collection
Select the result and expand by simple families.
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Total patents: 9630
Search Applicants and Owners separately: uni* illinois chicago
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Add to collection.
Select all patents in the collection and expand by simple families.
Add to collection. Total patents: 4560
Search Applicants and Owners separately: univ* AND Kansas. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 1781
Y is C(R8) or N;\n
Z is C(R9) or N;\n
X is CH2, O, N(R10), S, S(O) or S(O)2;\n
R1 is hydrogen, halogen, —N3, —CF3, —CCl3, —CBr3, —CI3, —CN, —COR1A, —OR1A, —NR1AR1B, —C(O)OR1A, —C(O)NR1AR1B, —NO2, —SR1A, —S(O)n1R1A, —S(O)n1OR1A, —S(O)n1NR1AR1B, —NHNR1AR1B, —ONR1AR1B, —NHC(O)NHNR1AR1B, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;\n
R4 is hydrogen, halogen, —N3, —CF3, —CCl3, —CBr3, —CI3, —CN, —COR4A, —OR4A, —NR4AR4B, —C(O)OR4A, —C(O)NR4AR4B, —NO2, —SR4A, S(O)n4R4A, —S(O)n4OR4A, —S(O)n4NR4AR4B, —NHNR4AR4B, —ONR4AR4B, —NHC(O)NHNR4AR4B, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;\n
R5 is independently hydrogen, halogen, —N3, —CF3, —CCl3, —CBr3, —CI3, —CN, —COR5A, —OR5A, —NR5AR5B, —C(O)OR5A, —C(O)NR5AR5B, —NO2, —SR5A, —S(O)n5R5A, —S(O)n5OR5A, —S(O)n5NR5AR5B, —NHNR5AR5B, —ONR5AR5B, —NHC(O)NHNR5AR5B, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, wherein R5 and R6 are optionally combined to form a substituted or unsubstituted cycloalkyl;\n
R6 is unsubstituted C1-C6 alkyl;\n
R8 is hydrogen, halogen, —N3, —CF3, —CCl3, —CBr3, —CI3, —CN, —COR8A, —OR8A, —NR8AR8B, —C(O)OR8A, —C(O)NR8AR8B, —NO2, —SR8A, —S(O)n8R8A, —S(O)n8OR8A, —S(O)n8NR8AR8B, —NHNR8AR8B, —ONR8AR8B, —NHC(O)NHNR8AR8B, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;\n
R9 is hydrogen, halogen, —N3, —CF3, —CCl3, —CBr3, —CI3, —CN, —COR9A, —OR9A, —NR9AR9B, —C(O)OR9A, —C(O)NR9AR9B, —NO2, —SR9A, —S(O)n9R9A, —S(O)n9OR9A, —S(O)n9NR9AR9B, —NHNR9AR8B, —ONR9AR9B, —NHC(O)NHNR9AR9B, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;\n
R10 is H, —CH3, —C2H5, —C3H7, —CH2C6H5;\n
R1A, R1B, R4A, R4B, R5A, R5B, R8A, R8B, R9A, and, R9B are independently hydrogen, oxo, halogen, —CF3, —CN, —OH, —NH2, —COOH, —CONH2, —NO2, —SH, —S(O)2Cl, —S(O)3H, —S(O)4H, —S(O)2NH2, —NHNH2, —ONH2, —NHC(O)NHNH2, —NHC(O)NH2, —NHS(O)2H, —NHC(O)H, —NHC(O)—OH, —NHOH, —OCF3, —OCHF2, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; and\n
n1, n4, n5, n8, and n9 are independently 1, 2, or 3."],"number":1,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 1, wherein is hydrogen."],"number":2,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 2, wherein R5 and R6 are each unsubstituted C1-C6 alkyl."],"number":3,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 3, wherein R1 is hydrogen, halogen, —OR1A, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl."],"number":4,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 4, wherein R1 is —OR1A, and R1A is substituted or unsubstituted alkyl, or substituted or unsubstituted heteroalkyl."],"number":5,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 5, wherein R1A is —CH3, —C2H5, —C3H7, —CD3, —CD2CD3, —(CH2)2OH, —(CH2)3OH, —CH2CH(OH)CH3, —(CH2)2CH(OH)CH3, —CH2C(CH3)2OH, —(CH2)2C(CH3)2OH, —(CH2)2F, —(CH2)3F, —CH2CH(F)CH3, —(CH2)2CH(F)CH3, —(CH2)2(CH3)2F, —(CH2)2Cl, —(CH2)3Cl, —CH2CH(Cl)CH3, —(CH2)2CH(Cl)CH3, —CH2C(CH3)2Cl, —(CH2)2C(CH3)2Cl, —(CH2)2NHSO2CH3, —(CH2)3NHSO2CH3, —(CH2)2N(CH2CH2OH)SO2CH3, —(CH2)3N(CH2CH2OH)SO2CH3, —(CH2)2N(CH2CH2F)SO2CH3, or —(CH2)2N(CH2CH2Cl)SO2CH3."],"number":6,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 6, wherein Y is C(R8)."],"number":7,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 7, wherein R8 is hydrogen, halogen, —OR8A, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl."],"number":8,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 8, wherein R8 is —OR8A, and R8A is hydrogen, substituted or unsubstituted alkyl, or substituted or unsubstituted heteroalkyl."],"number":9,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 9, wherein R8A is —CH3, —C2H5, —CD3, —CD2CD3, —(CH2)2OH, —(CH2CH2)3OH, —CH2C(CH3)2OH, —(CH2)2C(CH3)2OH, —(CH2)2F, —(CH2)3F, —CH2C(CH3)2F, or —(CH2)2C(CH3)2F."],"number":10,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 10, wherein Z is CH."],"number":11,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 11, wherein Xis S."],"number":12,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 1 having the formula:"],"number":13,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 13, wherein RiA is substituted or unsubstituted heterocycloalkyl."],"number":14,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 1 having the structure:"],"number":15,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 1 having the structure:"],"number":16,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 1 having the structure:"],"number":17,"annotation":false,"title":false,"claim":true},{"lines":["A pharmaceutical formulation, comprising the compound of claim 1 and a pharmaceutically acceptable excipient."],"number":18,"annotation":false,"title":false,"claim":true},{"lines":["A method of treating cancer in a subject in need thereof, comprising administering to the subject an effective amount of the compound of claim 1, wherein said cancer is a hematological malignancy."],"number":19,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}