{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"003-718-225-854-333","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"003-718-225-854-333"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":11703,"type":"PATENT","title":"Tel Aviv University - Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":6197,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8357,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately: tel aviv uni*
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Search Applicants and Owners separately: tel aviv uni*
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wherein:\n
n is 0, 1, or 2;\n
R1 is OH, C1 to C12 alkoxy, C1 to C12 substituted alkoxy, aryloxy, O-glucosyl or imino;\n
R2 is OH, C1 to C12 alkoxy, C1 to C12 substituted alkoxy, O-glucosyl, oxo, alkyl or imino;\n
R3, R4, R5, R6, R7, A, B, C, D and E are each independently H, halogen selected from the group consisting of bromo, iodo, fluoro and chloro, OH, C1 to C12 alkoxy, C1 to C substituted alkoxy, aryloxy, O-glucosyl, C1 to C12 alkyl or C1 to C12 substituted alkyl; provided that at least one of R6 and R7 is selected from the group consisting of bromo, iodo, fluoro and chloro;\n
wherein R1 and R2, or R1 and R4 may form together a lactone which is optionally substituted;\n
wherein the bonds between C3:C7, C4:C5, and C9:C10 may independently be double bonds or single bonds;\n
or a derivative of said formula, wherein the derivative has at least one of the following: a lower acyl side chain at C3 (free acid or ester or conjugate), a keto or hydroxy (free hydroxy or ester) moiety at the C6 carbon, or an n-pentenyl or n-pentyl side chain at C7;\n
including salts, hydrates, solvates, polymorphs, optical isomers, enantiomers, diastereomers, and mixtures thereof."],"number":1,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 1, wherein the bond between C9 and C10 is a single bond."],"number":2,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 1, wherein R2 is oxo."],"number":3,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 1, wherein each of A, B, R6 and R7 is selected from bromo, iodo, fluoro and chloro."],"number":4,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 1, wherein R1 is alkoxy."],"number":5,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 1, wherein R3, R4 and R5 are each H."],"number":6,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 1, wherein C, D and E are each H."],"number":7,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 1, wherein: n is 0; the bonds between C3:C7, C4:C5, and C9:C10 are single bonds; R1 is methoxy; R2 is oxo; R3, R4, R5, A, B, C, D and E are each H; and R6 and R7 are each bromo."],"number":8,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 1, wherein: n is 0; the bonds between C3:C7, C4:C5, and C9:C10 are single bonds; R1 is methoxy; R2 is O bound through a double bond to the carbon in position 6 thereby forming a carbonyl group; R3, R1, R5, C, D and E are each H; and A, B, R6 and R7 are each bromo."],"number":9,"annotation":false,"title":false,"claim":true},{"lines":["A pharmaceutical composition comprising a pharmaceutically acceptable carrier, and as an active ingredient a compound of claim 1."],"number":10,"annotation":false,"title":false,"claim":true},{"lines":["A pharmaceutical composition comprising a pharmaceutically acceptable carrier, and as an active ingredient a compound of claim 8."],"number":11,"annotation":false,"title":false,"claim":true},{"lines":["A pharmaceutical composition comprising a pharmaceutically acceptable carrier, and as an active ingredient a compound of claim 9."],"number":12,"annotation":false,"title":false,"claim":true},{"lines":["A method for reduction of the growth of cancer cells, comprising exposing the cancer cells to a therapeutically effective amount of a compound of claim 1."],"number":13,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 13 wherein the cancer is a mammalian cancer."],"number":14,"annotation":false,"title":false,"claim":true},{"lines":["A method for the treatment of cancer comprising administering to the subject in need thereof a pharmaceutical composition containing as an active ingredient a therapeutically effective amount of the compound according to claim 1."],"number":15,"annotation":false,"title":false,"claim":true},{"lines":["A method for the treatment of cancer comprising administering to the subject in need thereof a pharmaceutical composition containing as an active ingredient a therapeutically effective amount of the compound according to claim 8."],"number":16,"annotation":false,"title":false,"claim":true},{"lines":["The method according to claim 15, wherein the cancer is selected from the group consisting of carcinoma, sarcoma, adenoma, hepatocellular carcinoma, hepatoblastoma, rhabdomyosarcoma, esophageal carcinoma, thyroid carcinoma, ganglioblastoma, fibrosarcoma, myxosarcoma, liposarcoma, chondrosarcoma, osteogenic sarcoma, chordoma, angiosarcoma, endotheliosarcoma, lymphagiosarcoma, synovioama, Ewing's tumor, leimyosarcoma, rhabdotheliosarcoma, colon carcinoma, pancreatic cancer, breast cancer, ovarian cancer, prostate cancer, squamous cell carcinoma, basal cell carcinoma, adenocarcinoma, renal cell carcinoma, hematoma, bile duct carcinoma, melanoma, choriocarcinoma, seminoma, embryonal carcinoma, Wilms' tumor, cervical cancer, testicular tumor, lung carcinoma, small cell and non-small cell lung carcinoma, bladder carcinoma, epithelial carcinoma, glioma, astrocyoma, medulloblastoma, craniopharyngioma, ependynoma, pinealoma, retinoblastoma, rectal carcinoma, cancer of the thyroid, head and neck cancer, brain cancer, neuroblastoma, cancer of the endometrium, lymphoproliferative diseases, hematopoietic malignancies including all types of leukemia and lymphoma including: acute myelogenous leukemia, acute myelocytic leukemia, acute lymphocytic leukemia, chronic myelogenous leukemia, chronic lymphocytic leukemia, mast cell leukemia, multiple myeloma, myeloid lymphoma, Hodgkin's lymphoma, non-Hodgkin's lymphoma, as well as metastasis of all the above."],"number":17,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 15, wherein the cancer is selected from the group consisting of prostate cancer, breast cancer, skin cancer, colon cancer, lung cancer, pancreatic cancer, lymphoma, leukemia, head and neck cancer, kidney cancer, ovarian cancer, bone cancer liver cancer, melanoma and thyroid cancer."],"number":18,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 1, wherein R6 and R7 are each F."],"number":19,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 1, wherein R6 and R7 are each I."],"number":20,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 1, wherein R6 and R7 are each Cl."],"number":21,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 1, wherein R6 and R7 are each Br."],"number":22,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 1, wherein one of R6 and R7 is Br and the other is OH."],"number":23,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 1, wherein one of R6 and R7 is I and the other is OCH3."],"number":24,"annotation":false,"title":false,"claim":true},{"lines":["A method for the treatment of cancer comprising administering to the subject in need thereof a pharmaceutical composition containing as an active ingredient a therapeutically effective amount of the compound of Formula I:\n
wherein:\n
n is 0, 1, or 2;\n
R1 is OH, C1 to C12 alkoxy, C1 to C12 substituted alkoxy, aryloxy, O-glucosyl or imino;\n
R2 is OH, C1 to C12 alkoxy, C1 to C12 substituted alkoxy, O-glucosyl, oxo, alkyl or imino;\n
R3, R4, R5, R6, R7, A, B, C, D and E are each independently H, halogen, OH, C to C alkoxy, C to C substituted alkoxy, aryloxy, O-glucosyl, C1 to C12 alkyl or C1 to C12 substituted alkyl;\n
wherein R1 and R2, or R1 and R4 may form together a lactone which is optionally substituted;\n
wherein the bonds between C3:C7, C4:C5, and C9:C10 may independently be double bonds or single bonds;\n
provided that at least one of R3, R4, R5, R6, R7, A, B, C, D or E is a halogen; and provided that, if A is the only halogen in the compound, that A is not fluoro;\n
or a derivative of said formula, wherein the derivative has at least one of the following: a lower acyl side chain at C3 (free acid or ester or conjugate), a keto or hydroxy (free hydroxy or ester) moiety at the C6, carbon, or an n-pentenyl or n-pentyl side chain at C7;\n
including salts, hydrates, solvates, polymorphs, optical isomers, enantiomers, diastereomers, and mixtures thereof."],"number":25,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 25, wherein the cancer is selected from the group consisting of carcinoma, sarcoma, adenoma, hepatocellular carcinoma hepatoblastoma, rhabdomyosarcoma, esophageal carcinoma, thyroid carcinoma, ganglioblastoma, fibrosarcoma, myxosarcoma, liposarcoma, chondrosarcoma, osteogenic sarcoma, chordoma, angiosarcoma, endotheliosarcoma, lymphagiosarcoma, synovioama, Ewing's tumor, leimyosarcoma, rhabdotheliosarcoma, colon carcinoma, pancreatic cancer, breast cancer, ovarian cancer, prostate cancer, squamous cell carcinoma, basal cell carcinoma, adenocarcinoma, renal cell carcinoma, hematoma, bile duct carcinoma, melanoma, choriocarcinoma, seminoma, embryonal carcinoma, Wilms' tumor, cervical cancer, testicular tumor, lung carcinoma, small cell and non-small cell lung carcinoma, bladder carcinoma, epithelial carcinoma, glioma, astrocyoma, medulloblastoma, craniopharyngioma, ependynoma, pinealoma, retinoblastoma, rectal carcinoma, cancer of the thyroid, head and neck cancer, brain cancer, neuroblastoma, cancer of the endometrium, lymphoproliferative diseases, hematopoietic malignancies including all types of leukemia and lymphoma including: acute myelogenous leukemia, acute myelocytic leukemia, acute lymphocytic leukemia, chronic myelogenous leukemia, chronic lymphocytic leukemia, mast cell leukemia, multiple myeloma myeloid lymphoma, Hodgkin's lymphoma, non-Hodgkin's lymphoma, as well as metastasis of all the above."],"number":26,"annotation":false,"title":false,"claim":true},{"lines":["A compound of Formula I:\n
wherein:\n
n is 0, 1 or 2;\n
R1 is OH, C1 to C12 alkoxy, C1 to C12 substituted alkoxy, aryloxy, O-glucosyl or imino;\n
R2 is OH, C1 to C12 alkoxy, C1 to C12 substituted alkoxy, O-glucosyl, oxo, alkyl or imino;\n
R3, R4, R5, R6, R7, A, B, C, D and E are each independently H, halogen, OH, C to C alkoxy, C to C substituted alkoxy, aryloxy, O-glucosyl, C1 to C12 alkyl or C1 to C12 substituted alkyl; provided that at least one of R4, R5, R6, R7, B, C, D or E is a halogen;\n
wherein R1 and R2, or R1 and R4 may form together a lactone which is optionally substituted;\n
wherein the bonds between C3:C7, C4:C5, and C9:C10 may independently be double bonds or single bonds;\n
or a derivative of said formula, wherein the derivative has at least one of the following: a lower acyl side chain at C3 (free acid or ester or conjugate), a keto or hydroxy (free hydroxy or ester) moiety at the C6 carbon, or an n-pentenyl or n-pentyl side chain at C7;\n
including salts, hydrates, solvates, polymorphs, optical isomers, enantiomers, diastereomers, and mixtures thereof."],"number":27,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 27, wherein the bond between C9 and C10 is a single bond."],"number":28,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 27, wherein R2 is oxo."],"number":29,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 27, wherein R1 is alkoxy."],"number":30,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 27, wherein R3, R4 and R5 are each H."],"number":31,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 27, wherein C, D and E are each H."],"number":32,"annotation":false,"title":false,"claim":true},{"lines":["A pharmaceutical composition comprising a pharmaceutically acceptable carrier, and as an active ingredient a compound of claim 27."],"number":33,"annotation":false,"title":false,"claim":true},{"lines":["A method for reduction of the growth of cancer cells, comprising exposing the cancer cells to a therapeutically effective amount of a compound of claim 27."],"number":34,"annotation":false,"title":false,"claim":true},{"lines":["A method for the treatment of cancer comprising administering to the subject in need thereof a pharmaceutical composition containing as an active ingredient a therapeutically effective amount of the compound according to claim 27."],"number":35,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 35, wherein the cancer is selected from the group consisting of carcinoma, sarcoma, adenoma, hepatocellular carcinoma, hepatoblastoma, rhabdomyosarcoma, esophageal carcinoma, thyroid carcinoma, ganglioblastoma, fibrosarcoma, myxosarcoma, liposarcoma, chondrosarcoma, osteogenic sarcoma, chordoma, angiosarcoma, endotheliosarcoma, lymphagiosarcoma, synovioama Ewing's tumor, leimyosarcoma, rhabdotheliosarcoma, colon carcinoma, pancreatic cancer, breast cancer, ovarian cancer, prostate cancer, squamous cell carcinoma, basal cell carcinoma, adenocarcinoma, renal cell carcinoma, hematoma, bile duct carcinoma, melanoma, choriocarcinoma, seminoma, embryonal carcinoma, Wilms' tumor, cervical cancer, testicular tumor, lung carcinoma, small cell and non-small cell lung carcinoma, bladder carcinoma, epithelial carcinoma, glioma, astrocyoma, medulloblastoma, craniopharyngioma, ependynoma, pinealoma, retinoblastoma, rectal carcinoma, cancer of the thyroid, head and neck cancer, brain cancer, neuroblastoma, cancer of the endometrium, lymphoproliferative diseases, hematopoietic malignancies including all types of leukemia and lymphoma including: acute myelogenous leukemia, acute myelocytic leukemia, acute lymphocytic leukemia, chronic myelogenous leukemia, chronic lymphocytic leukemia, mast cell leukemia, multiple myeloma, myeloid lymphoma, Hodgkin's lymphoma, non-Hodgkin's lymphoma."],"number":36,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}