{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"002-036-567-025-143","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"002-036-567-025-143"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":6804,"type":"PATENT","title":"Univ Sydney Patent Portfolio","description":"Searched ' Univ Sydney ' for patent collection. Added owners (US), expanded by simply family and date range set as 01/Jan/2000 - 01/ Apr/ 2015\n","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":47811,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[],"sharedType":"PUBLISHED","hasLinkedSavedQueries":false,"savedQueries":[],"created":"2015-05-04T02:51:05Z","updated":"2015-05-04T04:00:52Z","lastEventDate":"2015-05-04T04:00:52Z"},{"id":6812,"type":"PATENT","title":"UNSW 2","description":"
Search Applicants= ' University of New South Wales' , ' Univ New South Wales' , ' UNSW', ' Univ* New Sou* Wal*' 'New Sou* Wal* Univ*', 'Univ* NEAR Ne* Sou* Wal*', 'Univ* AND Ne* Sou* Wal*'
Search Owners(US) = ' University of New South Wales' , ' Univ New South Wales' , ' UNSW', ' \nUniv* New Sou* Wal*' 'New Sou* Wal* Univ*', 'Univ* NEAR Ne* Sou* Wal*', \n'Univ* AND Ne* Sou* Wal*'
Select more for logical variants
Add to collection
Select all the patents in the collection and expand by simple families
Add to collection
Total patents = 1661
\n","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":1583,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[],"sharedType":"PUBLISHED","hasLinkedSavedQueries":false,"savedQueries":[],"created":"2015-05-04T06:37:15Z","updated":"2015-06-01T02:42:40Z","lastEventDate":"2015-06-01T02:42:40Z"},{"id":11644,"type":"PATENT","title":"The University of New South Wales - Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":1800,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8310,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"Search Applicants and Owners separately:new AND south AND wale
Select more for logical variants.
Add to collection.
Select all patents in the collection and expand by simple families.
Add to collection. Total patents: 1108
Search Applicants= ' University of New South Wales' , ' Univ New South Wales' , ' UNSW', ' Univ* New Sou* Wal*' 'New Sou* Wal* Univ*', 'Univ* NEAR Ne* Sou* Wal*', 'Univ* AND Ne* Sou* Wal*'
Search Owners(US) = ' University of New South Wales' , ' Univ New South Wales' , ' UNSW', ' \nUniv* New Sou* Wal*' 'New Sou* Wal* Univ*', 'Univ* NEAR Ne* Sou* Wal*', \n'Univ* AND Ne* Sou* Wal*'
Select more for logical variants
Add to collection
Select all the patents in the collection and expand by simple families
Add to collection
Total patents = 1661
\n","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":1583,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[],"sharedType":"PUBLISHED","hasLinkedSavedQueries":false,"savedQueries":[],"created":"2015-05-04T06:37:15Z","updated":"2015-06-01T02:42:40Z","lastEventDate":"2015-06-01T02:42:40Z"},{"id":11644,"type":"PATENT","title":"The University of New South Wales - Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":1800,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8310,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"Search Applicants and Owners separately:new AND south AND wale
Select more for logical variants.
Add to collection.
Select all patents in the collection and expand by simple families.
Add to collection. Total patents: 1108
a nucleic acid construct comprising a nucleotide sequence encoding a short hairpin RNA (shRNA) or an siRNA sequence specific to at least a portion of a class III β-tubulin gene, and
a pharmaceutically acceptable carrier, diluent or excipient,wherein expression of the construct is able to decrease the expression of class III β-tubulin in the tumour."],"number":2,"annotation":false,"title":false,"claim":true},{"lines":["An in vitro method for assessing the resistance of a tumour cell to a DNA-damaging agent, the method comprising detecting the expression of class III β-tubulin by the tumour cell, wherein when the class III β-tubulin amount in the tumour cell is higher than the control cell tubulin amount, the tumour cell is assessed as having greater resistance to the DNA damaging agent."],"number":3,"annotation":false,"title":false,"claim":true},{"lines":["A siRNA molecule comprising a nucleotide sequence specific to at least a portion of the class III β-tubulin gene product for use in increasing the sensitivity of a tumour cell to a DNA-damaging agent, wherein the siRNA molecule is able to decrease the expression of class III β-tubulin in the tumour cell to thereby increase sensitivity of the tumour cell to the DNA-damaging agent."],"number":4,"annotation":false,"title":false,"claim":true},{"lines":["A pharmaceutical composition for increasing the sensitivity of a tumour to a DNA-damaging agent, the pharmaceutical composition comprising
a siRNA molecule comprising a sequence specific to at least a portion of a class III β-tubulin gene, and
a pharmaceutically acceptable carrier, diluent or excipient,wherein introduction of the siRNA molecule to the tumour is able to decrease the expression of class III β-tubulin in the tumour."],"number":5,"annotation":false,"title":false,"claim":true},{"lines":["The construct of claim 1, the method of claim 3 or the molecule of claim 4, wherein the DNA damaging agent is selected from a platinum-based DNA damaging agent, cisplatin, doxorubicin or etoposide."],"number":6,"annotation":false,"title":false,"claim":true},{"lines":["The pharmaceutical composition of claim 2 or 5, wherein the DNA damaging agent is selected from a platinum-based DNA damaging agent, cisplatin, doxorubicin or etoposide."],"number":7,"annotation":false,"title":false,"claim":true},{"lines":["The construct of claim 1, wherein the nucleotide sequence encodes a short hairpin RNA (shRNA) or an siRNA sequence specific to at least a portion of the class III β-tubulin gene."],"number":8,"annotation":false,"title":false,"claim":true},{"lines":["The construct of claim 1 or claim 8, wherein a polycationic agent is used to deliver the construct to the cell, and the polycationic agent is polyethylenimine (PEI)."],"number":9,"annotation":false,"title":false,"claim":true},{"lines":["The molecule of claim 4, wherein a polycationic agent is used to deliver the molecule to the cell, and the polycationic agent is polyethylenimine (PEI)."],"number":10,"annotation":false,"title":false,"claim":true},{"lines":["The pharmaceutical composition of claim 2, 5 or 7, wherein the composition is conjugated to a polycationic agent, and the polycationic agent is polyethylenimine (PEI)."],"number":11,"annotation":false,"title":false,"claim":true},{"lines":["The construct of any one of claims 1, 6, 8 or 9, or the method of claim 3, or the molecule of any one of claims 4 or 10 wherein the tumour cell is a non-small-cell lung carcinoma cell (NSCLC)."],"number":12,"annotation":false,"title":false,"claim":true},{"lines":["The composition of any one of claims 2, 5, 7 and 11 wherein the tumour is a non-small cell lung carcinoma."],"number":13,"annotation":false,"title":false,"claim":true},{"lines":["The construct, method or molecule of claim 12, or the composition of claim 13, wherein the tumour cell is a human tumour cell."],"number":14,"annotation":false,"title":false,"claim":true},{"lines":["A nucleic acid construct comprising a nucleotide sequence specific to at least a portion of a class III β-tubulin gene product for use in treating a tumour cell in a subject, wherein the nucleic acid construct decreases the expression of class III β-tubulin in the tumour cell and thereby increases the sensitivity of the tumour cell to a tubulin-binding agent."],"number":15,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}