{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"001-807-437-707-572","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"001-807-437-707-572"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":8837,"type":"PATENT","title":"University of Minnesota Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":8933,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8208,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicant and Owners respectively = \"Univ Minnesota\" , \" Minnesota Univ\", \" University of Minnesota\", \"Minnesota University\", \"Univ Minne*\" , \" Minne* Univ*.
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Total patents: 7910
Search Applicant and Owners respectively = \"Univ Minnesota\" , \" Minnesota Univ\", \" University of Minnesota\", \"Minnesota University\", \"Univ Minne*\" , \" Minne* Univ*.
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Total patents: 7910
determining the level of at least one Reelin moiety in a biological sample from said patient, wherein said at least one Reelin moiety is chosen from a first Reelin moiety having an apparent molecular weight of about 410 kDa, a second Reelin moiety having an apparent molecular weight of about 180 kDa, and/or a third Reelin moiety having an apparent molecular weight of about 330 kDa, wherein said biological sample is selected from the group consisting of whole blood, plasma, and serum;\n
comparing said at least one Reelin level in said patient with the level of a corresponding Reelin moiety in one or more control subjects; and\n
diagnosing said major depression or said schizophrenia in said patient if:\n"],"number":1,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the diagnosis of major depression or schizophrenia is confirmed if:\n(a) when the levels of said first and said second Reelin moieties are determined, the level of said first Reelin moiety is not different from, or increased relative to, control subjects, and the level of said second Reelin moiety is decreased relative to said control subjects;\n(b) when the levels of said third and said second Reelin moieties are determined, the level of said third Reelin moiety is not different from, or is increased relative to, control subjects, and the level of said second Reelin moiety is decreased relative to said control subjects; and/or\n(c) when the levels of said first and said third Reelin moieties are determined, the level of said first Reelin moiety is not different from, or is increased relative to, control subjects, and the level of said third Reelin moiety is not different from, or is increased relative to, said control subjects.\n
in step (a), when the level of said third Reelin moiety is further determined, the level of said third Reelin moiety is not different from, or is increased relative to, said control subjects;\n
in step (b), when the level of said first Reelin moiety is further determined, the level of said first Reelin moiety is not different from, or is increased relative to, said control subjects; and/or\n
in step (c), when the level of said second Reelin moiety is further determined, the level of said second Reelin moiety is decreased relative to said control subjects."],"number":2,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein said level(s) is/are determined using an immunoassay."],"number":3,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 3, wherein said immunoassay is an ELISA."],"number":4,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 4, wherein said at least one Reelin moiety is captured with a polyclonal anti-Reelin antibody."],"number":5,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 4, wherein said at least one Reelin moiety is captured with a monoclonal anti-Reelin antibody."],"number":6,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}